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Pharmacokinetic disposition of cefotaxime in buffalo calves (Bubalus bubalis) following single intramuscular administration

Indian Agricultural Research Journals

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Title Pharmacokinetic disposition of cefotaxime in buffalo calves (Bubalus bubalis) following single intramuscular administration
 
Creator SHARMA, S K
SRIVASTAVA, A K
DEORE, M D
 
Subject Calves, Cefotaxime, Disposition kinetics, Dosage regimen
 
Description The pharmacokinetic disposition of cefotaxime was investigated in buffalo calves following its single intramuscular administration (10 mg.kg-1). The peak plasma concentration ofcefotaxime at 20 min was 11.3±0.4S µg.ml-1 which declined to 0.068±0.03 µg.ml-1 at 7 hr. The absorption half-life and elimination half-life were 0.145±0.047 and 1.24±0.07 hr respectively. The apparent volume of distribution and total body clearance were 1.17±0. 10L.kg-1 and 0.67±0.09 L.kg-1 hr respectively. Approximately 3.5% of the total administered drug was recovered in urine within 24 hr of its administration. An appropriate intramuscular dosage regimen for cefotaxime in buffalo calves would be 11 mg/kg repeated at 8 hr intervals.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2014-03-21
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/38850
 
Source The Indian Journal of Animal Sciences; Vol 74, No 6 (2004)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/38850/17470
 
Rights Copyright (c) 2014 The Indian Journal of Animal Sciences