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Influence of Escherichia coli lipopolysaccharide induced fever on the plasma kinetics of cefquinome in buffalo calves

Indian Agricultural Research Journals

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Title Influence of Escherichia coli lipopolysaccharide induced fever on the plasma kinetics of cefquinome in buffalo calves
 
Creator MANGAL, MUKESH
SHARMA, K
 
Subject Buffalo calves, Cefquinome, Dosage regimen, Fever, Pharmacokinetics
 
Description The pharmacokinetic behavior of cefquinome was studied in healthy and febrile buffalo calves after single intramuscular administration (2 mg/kg). The fever was induced with Escherichia coli lipopolysaccharide (1 μg/kg, IV). The drug concentration in plasma was detected by HPLC method. Pharmacokinetic analysis of disposition data indicated that intramuscular administration data were best described by one-compartment open model. At 2.5 min, concentrations of cefquinome in healthy and febrile animals were 2.21±0.38 and 2.52±0.38 μg/ml, respectively, and drug was detected up to 24 h. The peak plasma levels of cefquinome in febrile buffalo calves (7.70±0.46μg.ml-1) and healthy buffalo calves (6.70±0.46μg.ml-1) were achieved at 45 min and 30 min, respectively. The absorption half life (t1/2ka) of cefquinome was similar in healthy and febrile buffalo calves. Drug distribution was altered by fever as febrile animals showed volume of distribution (0.37±0.07L/kg) lower than healthy animal (0.69±0.04 L/ kg). Total body clearances in healthy and febrile animals were 0.09 and 0.04 L/kg/h, respectively. To maintain minimum therapeutic concentration of 0.1 mg/ml, a satisfactory dosage regimen of cefquinome in healthy and febrile buffalo calves would be 2.8 mg/kg and 1.2 mg/kg body weight, respectively, to be repeated at 24 h intervals.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2015-11-06
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/53044
 
Source The Indian Journal of Animal Sciences; Vol 85, No 11 (2015)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/53044/22347
 
Rights Copyright (c) 2015 The Indian Journal of Animal Sciences