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Defective interfering particles mediated early protection in animals against rinderpest*

Indian Agricultural Research Journals

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Title Defective interfering particles mediated early protection in animals against rinderpest*
 
Creator DHAR, P
BANDYOPADHYAY, S K
 
Subject Animal protection, Defective interfering particles, Rinderpest
 
Description Defective interfering (DI) particles were generated out of 4 serial undiluted passages of tissue culture rinderpest virus in vero Cells, leading to a persistent infection. These persistently infected cells supposedly contained DI particles that interfered with the replication of standard rinderpest virus, as detected in an in vitro interference assay. A preparation of such DI particles (the stock containing 5.85 x 106 particles/ml) was inoculated into rabbits and cattle and challenged animal were protected from the disearse, whereas simlar early protection was not evident with the live attenuated rinderpest vaccine. Use of such an approach in speedy control of diseases in field condition seems plausible.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2014-02-20
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/38088
 
Source The Indian Journal of Animal Sciences; Vol 72, No 12 (2002)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/38088/17106
 
Rights Copyright (c) 2014 The Indian Journal of Animal Sciences