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Disposition kinetics of gentamicin in normal and febrile goats following single dose intramuscular administration

Indian Agricultural Research Journals

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Title Disposition kinetics of gentamicin in normal and febrile goats following single dose intramuscular administration
 
Creator AHMAD, A H
SHARMA, L D
 
Subject Febrile goats, Goats, Gentamicin, Kinetic disposition
 
Description A study of the disposition kinetics of gentamicin was conducted in goats following single dose im administration (5 mg/kg). The effect of fever (induced by E. coli endotoxin) was observed on absorption, distribution and elimination of gentamicin. Serum concentrations of gentamicin Were detectable up to 6 hr in both groups of goats. Significant differences in serum concentrations of gentamicin were not observed at any time after injection between 2 groups of animals. The data were adequately described by a one- compartment model both in normal and febrile goats. Elimination half-life of 104.8 min in fertile goats was calculated. The volume of distribution (V d/F) was 192.5 ml/kg in febrile goats whereas in normal goats it was 158.0 ml/kg. Based on these pharmacokinetic parameters a dosage regimen for gentamicin was calculated.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2013-10-24
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/34378
 
Source The Indian Journal of Animal Sciences; Vol 67, No 5 (1997)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/34378/15264
 
Rights Copyright (c) 2014 The Indian Journal of Animal Sciences