Determination of lithium toxicity by apoptosis and different biomarkers on Carassius auratus (Linn.) tissues
NOPR - NISCAIR Online Periodicals Repository
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Title |
Determination of lithium toxicity by apoptosis and different biomarkers on Carassius auratus (Linn.) tissues
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Creator |
El-Tekreti, Sama Ammer Abbas
Yeltekin, Aslı Çilingir |
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Subject |
Antioxidants
Aquatic pollution Caspase-3 DNA damage Goldfish Heavy metal contamination |
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Description |
712-716
The widespread use of lithium, one of the heavy metals, in many industrial processes has significantly contaminated the groundwater as well as the surface water. Such contaminants enter into the food chain ecosystem and thereby challenge humans health. In fish, absorption of lithium is most likely through the default Na channel in the gills and muscle. In fish gills, the cell type primarily responsible for the regulation of atoms and ionic regulation are mitochondria-rich cells, also known as chloride cells. Here, we studied the effect of lithium toxicity on tissues of Goldfish, Carassius auratus (Linn.) as a model. We did spectrophotometric measurements to determine the effects of lithium dose (50 mg/L) in C. auratus at different times (24, 48, 72 and 96 h) of lithium dose. The results have shown LiCl induced alterations in CAT, SOD and GPx enzyme activities in the tissues of C. auratus depending on the concentration and duration of action at MDA, 8-OHdG and caspase-3 levels. Further, we observed increased levels of 8-OHG, modificationsof nucleotides, and DNA damage due to lithium toxicity. |
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Date |
2023-09-01T06:13:47Z
2023-09-01T06:13:47Z 2023-09 |
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Type |
Article
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Identifier |
0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62476 https://doi.org/10.56042/ijeb.v61i09.5115 |
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Language |
en
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Publisher |
NIScPR-CSIR, India
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Source |
IJEB Vol.61(09) [September 2023]
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