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Hepatoprotective activity of Trianthema portulacastrum L. against lipopolysaccharide/D-galactosamine induced hepatotoxicity in mice

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Title Hepatoprotective activity of Trianthema portulacastrum L. against lipopolysaccharide/D-galactosamine induced hepatotoxicity in mice
 
Creator Das, Uttam
Saha, Tanmay
Babu, Anindita Sinha
Das, Subir Kumar
 
Subject Antioxidants
Black Pigweed
Giant Pigweed
Hepatoprotective
Inflammation
Jejunum
Liver
 
Description 705-711
D-Galactosamine (D-GalN) is a well-established hepatotoxic
agent, whereas lipopolysaccharide (LPS) is a bacterial endotoxin;
and both in a combination induces the liver damage, which is
similar to a human hepatic diseases. In this study, we have
evaluated the hepatoprotective activity of the Giant or Black
Pigweed, Trianthema portulacastrum L. against D-galactosamine
in the presence of lipopolysaccharide (LPS/D-GalN) induced
hepatotoxicity using Swiss albino mice. LPS/D-GalN treatment
elevated the liver marker enzymes. The combined action of
LPS/D-GalN decreased the production of antioxidants such as
reduced glutathione (GSH), catalase, superoxide dismutase
(SOD), glutathione reductase (GR), glutathione peroxidase (GPx),
glutathione S-transferase (GST) and increase in the
malondialdehyde (MDA) and nitric oxide (NO) formation. Pretreatment
with T. portulacastrum (TP) extract showed dose
dependently attenuated liver marker enzymes, increased GSH
content, upregulated enzymatic activities of antioxidants in liver,
decreased MDA and NO formation. The results also revealed that
LPS/D-GalN-treatment increased the inflammation as observed
through neutrophil infiltrations and increased the formation of
sinusoids as evidenced from the histopathological studies of liver
tissue and the TP extract pre-treatment mitigated the neutrophil
infiltration and sinusoids formation dose dependently.
 
Date 2023-09-01T06:23:22Z
2023-09-01T06:26:31Z
2023-09-01T06:23:22Z
2023-09-01T06:26:31Z
2023-09
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62477
https://doi.org/10.56042/ijeb.v61i09.3784
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(09) [September 2023]