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Effect of KATP openers and blockers on AKT and mTOR mRNA levels in the hippocampus and cortex of rats with penicillin ınduced epilepsy

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Title Effect of KATP openers and blockers on AKT and mTOR mRNA levels in the hippocampus and cortex of rats with penicillin ınduced epilepsy
 
Creator Ümit, Kılıç
Hayriye, Soytürk
 
Subject Antidiabetic
Cellular stress
Epileptogenesis
Glibenclamide
Pinacidil
 
Description 681-686
Opening or closing of KATP channels affects some signaling pathways in the brain. These signaling pathways are thought
to be associated with epilepsy. Here, we investigated the effect of KATP channel opener and blocker on the AKT mTOR
mRNA expressions in the hippocampus and cortex regions in the penicillin model of epilepsy in rats. Four groups were
created viz. Control (C), Epilepsy (E), Epilepsy-Opener (E-O) and Epilepsy-Blocker (E-B). Epileptic focus was created by
administering penicillin into the brain, and the seizure-related AKT, mTOR mRNA levels were determined by qPCR on
days 1st, 4th, and 8th after the seizure. The AKT mRNA expression levels in the hippocampus were statistically significant
(P
 
Date 2023-09-01T06:56:07Z
2023-09-01T06:57:11Z
2023-09-01T06:56:07Z
2023-09-01T06:57:11Z
2023-09
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62480
https://doi.org/10.56042/ijeb.v61i09.1547
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(09) [September 2023]