Effect of KATP openers and blockers on AKT and mTOR mRNA levels in the hippocampus and cortex of rats with penicillin ınduced epilepsy
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Title |
Effect of KATP openers and blockers on AKT and mTOR mRNA levels in the hippocampus and cortex of rats with penicillin ınduced epilepsy
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Creator |
Ümit, Kılıç
Hayriye, Soytürk |
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Subject |
Antidiabetic
Cellular stress Epileptogenesis Glibenclamide Pinacidil |
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Description |
681-686
Opening or closing of KATP channels affects some signaling pathways in the brain. These signaling pathways are thought to be associated with epilepsy. Here, we investigated the effect of KATP channel opener and blocker on the AKT mTOR mRNA expressions in the hippocampus and cortex regions in the penicillin model of epilepsy in rats. Four groups were created viz. Control (C), Epilepsy (E), Epilepsy-Opener (E-O) and Epilepsy-Blocker (E-B). Epileptic focus was created by administering penicillin into the brain, and the seizure-related AKT, mTOR mRNA levels were determined by qPCR on days 1st, 4th, and 8th after the seizure. The AKT mRNA expression levels in the hippocampus were statistically significant (P |
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Date |
2023-09-01T06:56:07Z
2023-09-01T06:57:11Z 2023-09-01T06:56:07Z 2023-09-01T06:57:11Z 2023-09 |
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Type |
Article
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Identifier |
0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62480 https://doi.org/10.56042/ijeb.v61i09.1547 |
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Language |
en
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Publisher |
NIScPR-CSIR, India
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Source |
IJEB Vol.61(09) [September 2023]
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