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Observations on cellular response in experimentally sheep-pox-infected lambs

Indian Agricultural Research Journals

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Title Observations on cellular response in experimentally sheep-pox-infected lambs
 
Creator BACHH, A S
RAM, G C
HOPKINS, J
BANSAL, M P
 
Subject Cellular response, Sheep-pox, Lambs
 
Description The observation on T cell mediated responses in experimentally sheep-pox virus (SPV)-infected lambs, was made on the basis of virus (SPV) antigen induced lymphocyte proliferation, interleukin-2 (IL-2) production ability of peripheral blood lymphocytes (PBL), IL-2 receptor expression, leucocyte migration inhibition (LMIA) and lymphocyte subset alteration in the peripheral blood by using panel of mouse monpclonal antibodies to sheep leucocyte antigen designated as CD4, CDS, CDS. T19. CD4S. C02, B.MHC class I and MHC class II. The sequential changes in PBL subset population with considerable decrease in C08+ ratio (30.5 to 1.26) in the post-infection period of lambs were significant. The specific viral antigen induced Iymphocyte blastogenesis and release of increased amounts of soluble factors especially IL-2 post viral infection is regarded as an in vitro correlate of cell-mediated immune response (CMI)against pox.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2013-10-24
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/34318
 
Source The Indian Journal of Animal Sciences; Vol 67, No 4 (1997)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/34318/15223
 
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