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Comparative pharmacokinetics of cefotaxime in normal cyclic and endometritis affected buffaloes

Indian Agricultural Research Journals

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Title Comparative pharmacokinetics of cefotaxime in normal cyclic and endometritis affected buffaloes
 
Creator Singh, Satinderpal
Gandotra, V K
Sharma, S K
Srivastava, A K
 
Subject Buffaloes; Cefotaxime; Endometritis; Pharmaeokinetics
 
Description The pharmaeokinetics and dosage regimen of cefotaxime were investigated in normal cyclic and endometritis affected buffaloes (6 each). Cefotaxime was administered @10mg.kg-1 b.wt by intramuscular injection in all animals. In normal cyclic buffaloes, peak concentration of cefotaxime reached was 8.16±0.04 µ.ml¯¹ at 15 min and the drug was detected up to 8 hr, while in endometritis affected buffaloes,the plasma levels were significantly lower than the normal cyclic buffaloes, but the drug was detected up to 12 hr. In normal cyclic buffaloes, the absorption half-life, elimination half-life volume of distribution and MRT (mean rersidence time) values were 0.85±0.27 hr, 187±0.08 hr,1.62±0.04 L.kg¯¹ and 2.83±0.12 hr respectively, while in endomitritis affected buffaloes, the corresponding values was 0.19±0.05 h,5.12±0.78 hr, 3.24±0.38L.kg¯¹ and 7.49±1.10 hr, respectively. Uterine concentration of cefotaxime was comparatively
more in endometritis affected buffaloes than normal cycling buffaloes. To maintain a minimum therapeutic concentration of 1 µg.kg¯¹ b.wt..a satisfactory dosage regimen of cefotaxime in endometritis affected buffaloes was 12 mg.kg¯¹ followed by 8.5 mg.kg¯¹ at 8hr intervals.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Date 2005-12-05
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/9388
 
Source The Indian Journal of Animal Sciences; Vol 75, No 12 (2005)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/9388/4123
 
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