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Disposition kinetics and bone penetration of ampicillin and cefazolin during fracture repair in dogs

Indian Agricultural Research Journals

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Title Disposition kinetics and bone penetration of ampicillin and cefazolin during fracture repair in dogs
 
Creator Singh, Balroop
Srivastava, A K
Sharma, S N
 
Subject Ampicillin; Bone penetration; Cephazolin; Disposition kinetics; Dog; Fracture repair
 
Description Ampicillin and cefazolin were given intravenously @ 10mg/kg.b. wt. after repair of fracture with intramedullary pin.Following single intravenous administration the distributilm half-life (t1/2alfa) , elimination half life (t1/2beeta) and Vd (area) of ampicillin were 0.458hr. 3.27br and 0.625 L.kg-1, respectively, and for cefazolin 0.347hr, 2.03 hr and 0.333 L.kg-1, respectively. The concentration of ampicillin in muscle at 1 and 2 hr were 5.27±0.46 and 4.3±0.1 µg/g, respectively, and in bone at 2 hr was 4.38±0.13 µg/g. The level of cefazolin in muscle at 1 and 2 hr were 5.14±0.34 and 5.14±0.17 µg/g. respectively, and in bone at 2 hr 5.24±0.24 µg/g. Both the antibiotics are having sufficient penetration in bone and surrounding muscles and can be recommended in the management of bacterial infection during orthopaedic Surgery.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2012-06-08
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/19258
 
Source The Indian Journal of Animal Sciences; Vol 68, No 1 (1998)
0367-8318
 
Language en
 
Rights Copyright (c) 2014 The Indian Journal of Animal Sciences