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Paralytic effect of fasciolicidal agents on rhythmic motility of Fasciola gigantica

Indian Agricultural Research Journals

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Title Paralytic effect of fasciolicidal agents on rhythmic motility of Fasciola gigantica
 
Creator Kumar, D
Tripathi, H C
 
Subject Fasciola gigantica; Fasciolicides; Paralysis
 
Description Effect of some clinically used fasciolicides was assessed on the rhythmic motility of Fasciola gigantica to evaluate their possible action on the neuromuscular system of the fluke. The mature flukes collected from the local abattoir were either mounted isometrically or incubated in Hedon-Fleig solution. Hexachlorophene (10-6 M), niclofolan (10-5 M) and oxyclozanide (10-6 M) induced rapid, persistent and tonic paralysis of the flukes. However, rafoxanide (3 x 10-4 M) caused slow, partial and flaccid paralysis of the fluke. Albendazole and triclabendazole did not show any paralytic effect on fluke rhythmicity. The gross visual motility was inhibited completely within half an hour of incubation and the flukes were paralyzed in tonic state by hexachlorophene ( 10-5 M), niclofolan ( 10-5 M) and oxyclozanide (10-5 M), while the same was inhibited slowly by rafoxanide, albendazole and triclabendazole. It is concluded from the results that hexachlorophene, niclofolan and oxyclozanide produced their fasciolicidal effect by affecting neuromuscular system of the fluke whereas rafoxanide, albendazole and triclabendazole may have effect on energy metabolism and or may be affecting the tegument of the fluke. The results may facilitate developing combination therapy against F. gigantica.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2012-07-26
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/22414
 
Source The Indian Journal of Animal Sciences; Vol 68, No 11 (1998)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/22414/11008
 
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