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An association study of SNPs with susceptibility to bovine paratuberculosis infection in cattle

Indian Agricultural Research Journals

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Title An association study of SNPs with susceptibility to bovine paratuberculosis infection in cattle
 
Creator YADAV, RAMJI
SHARMA, A K
SINGH, RANVIR
SONWANE, ARWIND
KUMAR, AMIT
CHAUHAN, ANUJ
KUMAR, SUBODH
KUMAR, TARUN
R, RENJITH
BHALADHARE, ASHISH
PRAKASH, OM
BAQIR, MOHD
SHARMA, DEEPAK
 
Subject Cattle, MAP, Paratuberculosis, Quantitative trait loci, SNP
 
Description The study was conducted to identify SNPs of quantitative trait loci (QTL) associated with susceptibility to Mycobacterium avium ssp. paratuberculosis (MAP) infection in cattle. Total 20 SNPs from the cattle QTL database were selected on the basis of the potential role in Mycobacterium susceptibility and a case: control association study was conducted in cattle. Out of 20 SNPs total 17 SNPs were polymorphic and 3 were monomorphic in population. The SNP (rs41945014) was significantly associated with MAP and revealed that ODDs of GG and GT genotypes verses TT genotype were 1.22 (0.33–4.49; 95% CI) and 3.37 (1.23–9.23; 95% CI), respectively. The proportion of GG and GT genotypes were significantly higher in bovine paratuberculosis positive animals suggested that selection against these 2 genotypes may confer resistance against bovine paratuberculosis. The all other 16 polymorphic SNPs of the present investigation were not differing significantly in case-control animals.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2014-05-15
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/40643
 
Source The Indian Journal of Animal Sciences; Vol 84, No 5 (2014)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/40643/18196
 
Rights Copyright (c) 2014 The Indian Journal of Animal Sciences