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Trend of association of BoLA-DQA1 alleles with FMDV vaccine elicited immune response in crossbred cattle

Indian Agricultural Research Journals

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Title Trend of association of BoLA-DQA1 alleles with FMDV vaccine elicited immune response in crossbred cattle
 
Creator VANDRE, R K
SHARMA, A K
GOWANE, G R
SANKAR, M
SANYAL, A
BISHT, POONAM
PATTNAIK, B
 
Subject Bovine leukocyte antigen, Crossbred cattle, DQA1, FMD, Foot and mouth disease
 
Description Major histocompatibility complex molecules play a major role in immunological defense against pathogens. Polymorphism of bovine leukocyte antigen (BoLA) DQA1 gene is being intensively investigated for potential association with economically important diseases of cattle. Accordingly, we investigated the association of DQA1 Exon 2 polymorphism as evidenced by the variation in the binding pockets with variability in immune response to inactivated trivalent (O, A and Asia1) foot and mouth disease virus (FMDV) vaccine in a closed population of crossbred cattle. Antibody titer of >1.8 was set as the cutoff value to distinguish the protected (> 1.8) and unprotected (1] for a good proportion of DQA1 alleles in a given serotype. The knowledge has potential implications in future selection programmes if integrated with the complete BoLA haplotype details and production traits of the herd.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2014-06-23
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/41569
 
Source The Indian Journal of Animal Sciences; Vol 84, No 6 (2014)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/41569/18531
 
Rights Copyright (c) 2014 The Indian Journal of Animal Sciences