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Histopathological and histochemical changes in thyroid and liver during starvation in drug induced hypothyroid albino rats

Indian Agricultural Research Journals

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Title Histopathological and histochemical changes in thyroid and liver during starvation in drug induced hypothyroid albino rats
 
Creator Goyal, Meenakshi
Singh, Sukhdev
Roy, K S
Soni, G
 
Subject Hypothyroidism; Rat; Starvation, Thyroid
 
Description The present investigation was carried out to study the histopathological changes occurred due to thyroid malfunction and starvation in rats. Rats were divided into 4 groups. After inducing hypothyroidism in groups 2, 3 and 4 by administrating carbimazole (5 mg/d/100g bw) in feed for 22 days, the rats of groups 3 and 4 were kept on fast for 48 and 72 hr
respsctivcly. Group 1 taken as euthroid control. After sacrifice, the samples of thyroid and liver were fixed in 10% neutral buffered formalin for histopathological studies. Blood was collected for assessment of thyroid hormones.Included hypothyroid rats showed hypertrophy and hyperplasia ol'follicullar epithelium, devoid of colloid material and increased capillary network in thyroid gland as compared to euthyroid rat. Thyroid section of 48 and 72 hr starved hypothyroid rats. in addition to hypertrophied follicles, showed dialation and marked increase in the number of blood vessels. Severe necrotic changes were observed in hepatic tissues of 48 and 72 hr fasted induced hypothyroid rats.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Date 2005-02-05
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/8109
 
Source The Indian Journal of Animal Sciences; Vol 75, No 2 (2005)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/8109/3140
 
Rights Copyright (c) 2014 The Indian Journal of Animal Sciences