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Prevalence of benzimidazole resistant ß- tubulin alleles in Haemonchus contortus larvae from sheep of Rajasthan

Indian Agricultural Research Journals

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Title Prevalence of benzimidazole resistant ß- tubulin alleles in Haemonchus contortus larvae from sheep of Rajasthan
 
Creator SWARNKAR, C P
SINGH, D
KUMAR, SATISH
 
Subject Anthelmintic resistance; Benzimidaole; ß-tubulin; Haemonchus contortus; Refugia; Sheep
 
Description The study was conducted to find out the feasibility of community dilution strategy in worm population for reversion to susceptibility against benzimidazole (BZ) anthelmintics. The prevalence of BZ-resistant ß- tubulin alleles was determined through allele specific polymerase chain reaction (AS-PCR) in 1216 infective larvae of Haemonchus contortus isolated from sheep flocks of different origins. Both management of flocks and agro-climate has significant influence on the prevalence of homozygous BZ-resistant (rr) genotypes. The overall frequency of rr genotypes was relatively low in farm flocks and in arid Rajasthan. The maximum prevalence of BZ-susceptible was observed during winter (51.00%) and monsoon (24.59%) in arid and semi-arid farm. In field flocks, there was a moderate rise in proportion of BZsusceptible genotypes during monsoon. The study exhibited that community dilution strategy for reversion of susceptibility to BZ anthelmintics in H. contortus could be feasible in farm conditions. The period from September to November in semi-arid and from June to February in arid agroclimatic conditions seem to be appropriate in increasing the frequency of BZ-susceptible alleles in the refugia.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2012-12-12
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/25658
 
Source The Indian Journal of Animal Sciences; Vol 82, No 12 (2012)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/25658/11864
 
Rights Copyright (c) 2014 The Indian Journal of Animal Sciences