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Changes in angiotensin converting enzyme, electrocardiograms and histology during sedation and general anaesthesia in dogs

Indian Agricultural Research Journals

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Title Changes in angiotensin converting enzyme, electrocardiograms and histology during sedation and general anaesthesia in dogs
 
Creator SHARMA, A K
SHAHI, APRA
KUMAR, NAVEEN
MAITI, S K
., JAGMOHAN
SINGH, R
 
Subject Angiotensin converting enzyme; Anaesthesia; Arterial blood pressure; Dogs; Electrocardiogram
 
Description In present study, 16 dogs were divided into 4 equal groups to study the status of angiotensin converting enzyme, electrocardiograms and histomorphology in sedated and anaesthetized dogs. All the dogs were premedicated with atropine sulphate (0.045 mg/kg). After 20 min, detomidine (0.2 mg/kg) in groups 1 and 3 and xylazine (2 mg/kg) in groups 2 and 4 were intramuscularly injected, followed by thiopental sodium after 15 min, intravenously, till-effect for anaesthetic induction in animals of groups 3 and 4. The angiotensin converting enzyme (ACE) activity was found significantly increased at 15–45 min in group 1 and at 30 min in group 2. Whereas, significant increase in ACE in animals of groups 3 and 4 was recorded at 5–15 min and 5 min, respectively. The significant hypertension persisted for 60 min in animals of groups 1 and 3, and for 30 min in animals of groups 2 and 4. In groups 1 and 2, sino-atrial block in all dogs and second degree AV block in 1 dog of each group were seen within 2–15 min of drug administration. Ventricular premature contractions at 15–30 min were recorded in 1 dog of group 2 and group 4. The plasma electrolytes were nonsignificantly altered. Microscopically, haemorrhages with engorgement of blood vessels was seen in the parenchymatous organs. In lungs, the haemorrhages along with mild edema were seen in the perivascular areas and alveoli. Both xylazine and detomidine with and without thiopental sodium had increased the ACE activity, which resulted in proportionate hypertension, alongwith changes in alveolar epithelium and pulmonary endothelium during peak effect. 
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2011-03-23
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/5138
 
Source The Indian Journal of Animal Sciences; Vol 79, No 1 (2009)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/5138/2176
 
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