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Wound healing activity of methanolic extract of leaves of Achyranthes aspera Linn using in vivo and in vitro model—a preliminary study

Indian Agricultural Research Journals

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Title Wound healing activity of methanolic extract of leaves of Achyranthes aspera Linn using in vivo and in vitro model—a preliminary study
 
Creator BARUA, CHANDANA C
BEGUM, SHAMEEM A
TALUKDAR, ARCHANA
PATHAK, DEBESH C
SARMA, DILIP K
BORA, RUMI S
 
Subject Achyranthes aspera; Chorioallantoic membrane model; Excision wound; Incision wound
 
Description Wound healing activity of methanolic extract of Achyranthes aspera Linn. was evaluated by excision and incision wound model (in vivo) in Sprague Dawley rats and by chorioallantoic membrane (CAM) model (in vitro) in 9-day-old embryonated chicken eggs. In excision wound, there was 82.23% wound contraction in control group on 21st day, whereas in A. aspera treated group, complete healing took place on 21st day. In the standard group, the wound persisted beyond 21st day. These findings were confirmed by histopathological examination. In incision wound, tensile strength of the healing tissue of A. aspera treated group was comparable with standard group and both were significantly higher compared to the control group. In CAM model, angiogenesis in A. aspera treated group @ 400 μg/disc was compared to the control group suggesting promising wound healing activity of methanolic extract of A. aspera.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor ICAR
 
Date 2010-10-18
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/1505
 
Source The Indian Journal of Animal Sciences; Vol 80, No 10 (2010)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/1505/446
 
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