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Synthesis, characterization and in vitro antitumor activities of a biimidazolechelated Ir(III) complex

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Title Synthesis, characterization and in vitro antitumor activities of a biimidazolechelated Ir(III) complex
 
Creator Ouyang, Miao
Hu, Ping
Cai, Hong
Chen, Yanhuai
Lin, Hongzhao
 
Subject Cyclometalated iridium(III) complex
1-Methyl-2
2'-biimidazole
PDT
Photosensitizer
 
Description 950-955
In this paper, a new cyclometalated iridium(III) complex [Ir(ppy)2(mbiim)]Cl (Ir3) (in which mbiim = 1-Methyl-2,2'-
biimidazole, ppy = 2-phenylpyridine) has been successfully synthesized and characterized by ESI-MS, UV-Vis spectroscopy
and 1H NMR. The fluorescence properties of Ir3 have been studied in different pH value conditions. The fluorescence
properties show that the fluorescence intensity of Ir3 decreases with the increase of pH in the experiment range, which is
due to the protonation/deprotonation of active hydrogen of the imidazole ring on the imidazole ligand. Moreover, the
photodynamic antitumor activities in vitro of three Ir(III) complexes have been investigated by MTT assay against four cell
lines (HeLa, A549, A549R and LO2). These complexes exhibit low dark toxicity and high phototoxicity in three tumor cells.
To our excitement, Ir3 has achieved satisfactory photodynamic therapy effects on cisplatin-resistant tumor cell lines A549R,
while its toxicity towards normal cells is relatively lower. The results indicate that Ir3 is a relatively ideal photosensitizer,
which may be developed into a new potential photodynamic therapy reagent against tumor.
 
Date 2023-09-19T05:09:51Z
2023-09-19T05:09:51Z
2023-09
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/62516
https://doi.org/10.56042/ijc.v62i9.5359
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.62(09) [September 2023]