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Determination of alpha-lipoic acid in pharmaceutical samples using inhibitory kinetic approach in SLS micellar medium

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Title Determination of alpha-lipoic acid in pharmaceutical samples using inhibitory kinetic approach in SLS micellar medium
 
Creator Srivastava, Abhishek
Srivastava, Neetu
Singh, Ruchi
 
Subject Inhibitory effect
Alpha-lipoic acid
Surfactant medium
Pharmaceutical preparations
Hexacyano ferrate (II)
Excipients
 
Description 931-939
A novel, repeatable, and swift kinetic approach for determining alpha-lipoic acid (ALA) in sodium lauryl sulfate
(SLS) micellar medium has been presented, and it has been connected to ALA determination in drug formulations. The
approach is based on ALA inhibitory property. ALA (containing two sulfur atoms) forms a chelate with Pd2+, lowering the
effective [Pd(II)], and ultimately, the Pd2+catalyzed cyanide substitution rate from [Fe(CN)6]4− by 4-cyanopyridine
(4-CNpy). Fixed times of 5 and 10 min have been chosen under optimal reaction conditions with [4-CNpy] = 2.0 × 10−3
mole dm−3, pH = 3.50 ± 0.02, Temp = 298 ± 0.2 K, I = 0.1 mole dm−3 (NaClO4), [Fe(CN)6
4−] = 1.25 × 10−4 mole dm−3,
[Pd+2] = 6.0 × 10−5 mole dm−3, and [SLS] = 7.75 × 10−3 mole dm−3 to calculate the absorbance at 477 nm associated with the
final substitution product [Fe(CN)5 4-CNpy]3−. ALA's inhibiting influence on the Pd2+catalyzed cyanide substitution with
4-CNpy from [Fe(CN)6]4−, has been represented by a modified mechanistic approach. The concentration of ALA in various
water specimens can be measured at the micro-level down to 1.0 × 10−6 mole dm−3 using the established kinetic
spectrophotometric approach. The suggested method is highly reproducible and has been effectively applied to accurately
quantify the ALA in pharmaceutical samples. Even as much as 1000 with [ALA], typical additives used in medications do
not significantly hinder the determination of ALA.
 
Date 2023-09-19T05:18:36Z
2023-09-19T05:18:36Z
2023-09
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/62519
https://doi.org/10.56042/ijc.v62i9.2574
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.62(09) [September 2023]