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Protein Carbamylation in Neurodegeneration and other age-related disorders

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Title Protein Carbamylation in Neurodegeneration and other age-related disorders
 
Creator Bhavsar, Krishna
Shekhar, Vivek
Gupta, Sharad
 
Subject Age-related disorders
Carbamylation
Neurodegenerative diseases
Post-translational modifications
 
Description 659-665
Ageing is a complex process that is greatly influenced by environmental and genetic factors. Ageing at the cellular and
molecular level is characterized by the accumulation of post-translationally modified proteins that are derogative to cells,
termed Degenerative protein modification (DPM). A particular class of DPM, occurring under the impact of urea, termed
brain ureido degenerative post-translational modifications (uDPM) has also been implicated in the molecular pathogenesis
of Alzheimer's disease and related neurodegenerative disorders. These modifications can disrupt normal protein functions by
altering their conformation, enzymatic activities, receptor recognitions, and physiological capabilities. Carbamylation is an
age-related uDPM that results from the non-enzymatic modification of amino groups of ε-amino groups on lysine in
proteins. The significance of carbamylation in some age-related disorders such as cataracts, rheumatoid arthritis,and
cardiovascular diseases is well documented.However, the role of carbamylation in the pathogenesis of various
neurodegenerative disorders, which are also age-dependent, has not been explored much. The aim of the current article is a
retrospection of carbamylation, its effect on proteins, and its implications in ageing and neurodegenerative diseases.
 
Date 2023-09-20T05:24:24Z
2023-09-20T05:24:24Z
2023-09
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/62537
https://doi.org/10.56042/ijbb.v60i9.4103
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJBB Vol.60(09) [September 2023]