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Mechanistic insights into the oncogenic partnership of hADA3 and HPVE6 - paving ways for improved cervical cancer therapy

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Title Mechanistic insights into the oncogenic partnership of hADA3 and HPVE6 - paving ways for improved cervical cancer therapy
 
Creator Pradhan, Santonu Kumar
Sahani, Nandini
Preeti
Nag, Alo
 
Subject Cervical cancer
E6
hADA3
HPV
Peptide
SUMOylation
 
Description 651-658
High risk Human Papillomavirus (HPV) is considered the primary causative agent of cervical cancer, a deva`stating malady
with significant morbidity. In India, cervical cancer is one of the major reasons of cancer mortality among women. Poor
treatment outcomes of this disease is a matter of grave concern and hence demands aggressive research efforts towards
discovery of more effective therapies. Understanding the intricacies of HPV oncogenesis at the molecular level can facilitate
the discovery of promising anti-viral drugs. Our research aims at catering to the need of the time by revealing some of the
key molecular mechanisms that contributes to HPV oncogenesis that can be utilized to discover promising anti-cancer
molecules. We delineated the oncogenic connections between hADA3 and HPVE6 and illustrated its critical role in cellular
transformation. Our work also shows how HPV oncoproteins exploits the cellular SUMO machinery to downregulate
hADA3 to induce malignancy. This intrigued us to identify the hot spots of hADA3-E6 interaction and design therapeutic
peptides against HPV induced cervical cancer. Present review is an attempt to outline our research on novel mechanisms of
HPV pathogenesis and its implication on development of improved cervical cancer therapies.
 
Date 2023-09-20T05:26:24Z
2023-09-20T05:26:24Z
2023-09
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/62538
https://doi.org/10.56042/ijbb.v60i9.4162
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJBB Vol.60(09) [September 2023]