Record Details

A Vibrational Spectroscopic Method for Detection of Rheumatoid Arthritis using Bodily Fluids

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title A Vibrational Spectroscopic Method for Detection of Rheumatoid Arthritis using Bodily Fluids
 
Creator Garnaik, Umesh Chandra
Agarwal, Shilpi
 
Subject Rheumatoid arthritis
Raman spectroscopy
Nucleic acids
TNF-α
 
Description 807-809
Rheumatoid arthritis (RA) has a significant level of clinical variability and is also diagnosed based on a variety of
clinical factors. The absence of bio-marker prediction approach makes prompt identification and therapeutic diagnosis of these
individuals difficult. With the advent of targeted medicines, it has become increasingly crucial to diagnose RA early in order
to provide safe and timely disease management that can minimize long-term consequences that include joint tissue damage.
Raman spectroscopy is currently gaining clinical acceptability as a label-free, non-invasive tool for obtaining a thorough
biochemical signature of biological sample composition. The purpose of this research was to look at using confocal Raman
spectroscopy in conjunction with statistical data analysis as an auxiliary or supplementary tool for completing the diagnostic
process of RA using peripheral blood serum. Raman intensities and Functional group frequencies are assigned to amide
chains in proteins and other intermediate structural components such as lipids of a normal individual and a RA patient were
distinguished, and biochemical alterations were found. Experimental results shows that spectral shift in region I and region II
in Figure 1 identifies the concentration of nucleic acids and TNF-α increases respectively, which causes inflammation in our
body that initiates RA disease.
 
Date 2023-09-21T05:15:53Z
2023-09-21T05:15:53Z
2023-09
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/62551
https://doi.org/10.56042/ijpap.v61i9.3114
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJPAP Vol.61(09) [September 2023]