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<p>Hepatoprotective and antioxidant activity of <em>Persicaria maculosa</em> aqueous extract against carbon tetrachloride induced hepatotoxicity in Wistar rats</p>

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Title Statement <p>Hepatoprotective and antioxidant activity of <em>Persicaria maculosa</em> aqueous extract against carbon tetrachloride induced hepatotoxicity in Wistar rats</p>
 
Added Entry - Uncontrolled Name Dar, Mohd Shafi; Sri Satya Sai University of Technology and Medical Sciences, Sehore Madhya Pradesh, India
Mittal, Deepak Kumar; Sri Satya Sai University of Technology and Medical Sciences, Sehore, Madhya Pradesh 466 001, India
Tahir, Abu ; Rajiv Gandhi Proudyogiki Vishwavidhyalay Madhya Pradesh 462 033, India
 
Uncontrolled Index Term Carbon Tetrachloride, Hepatoprotective, Marker enzymes, Persicaria maculosa, Silymarin
 
Summary, etc. <p>The consolidated hepatoprotective effect and antioxidant activity of <em>Persicaria maculosa </em>Gray were assessed against carbon tetrachloride (CCl<sub>4</sub>) instigated hepatic harm in Wistar albino rats. Aqueous extract of <em>P. maculosa </em>at a dosage of 400 mg kg<sup>-1</sup>. Every 14 days, a portion of one's body weight was administered orally. The generously raised serum marker catalysts for example, ALT, ALP, AST, total bilirubin and the cell reinforcement proteins, for instance, glutathione reductase, glutathione peroxidase, and glutathione-S-transferase were discovered as a result of CCl<sub>4 </sub>treatment. Following administration of plant extract, the levels of the previously mentioned enzymes were brought close to approaching regularity. At a dose of 100 mg/kg, silymarin was used as a standard reference drug in the study. The results of this study demonstrated unequivocally that <em>P</em><em>ersicaria</em> <em>maculosa</em> has a potent hepatoprotective effect in rats against CCl<sub>4</sub>-induced hepatic damage. Histopathological changes were also seen in livers of animals that received drugs. Simultaneous organization of silymarin altogether diminished the medications-induced biochemical and histological changes toward normalcy.</p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2023-09-26 16:12:41
 
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http://op.niscair.res.in/index.php/IJTK/article/view/45493
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 22, ##issue.no## 3 (2023): Indian Journal of Traditional Knowledge
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJTK/article/download/45493/465545706