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<p>An investigation of the anti-hypertensive effect of mad honey and <em>Rhododendron luteum </em>sweet extract induced by N- ω -Nitro L-Arginine Methyl Ester (L-NAME) in rats</p>

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Title Statement <p>An investigation of the anti-hypertensive effect of mad honey and <em>Rhododendron luteum </em>sweet extract induced by N- ω -Nitro L-Arginine Methyl Ester (L-NAME) in rats</p>
 
Added Entry - Uncontrolled Name Çakır, Hilal Ebru; Karadeniz Technical University
Malkoç, Meltem ; Karadeniz Technical University
Sahin, Huseyin ; Giresun University
Kara, Yakup ; Karadeniz Technical University
Kolaylı, Sevgi ; Karadeniz Technical University
This study was supported by the Karadeniz Technical University (BAP 06) FDK-2019-8046 project
 
Uncontrolled Index Term Grayanotoxin, Hypertensive, Mad honey, Rhododendron
 
Summary, etc. <p>The aim of this study was to investigate the anti-hypertensive effect of mad honey and <em>Rhododendron luteum </em>sweet extracts containing grayanotoxin (GTX)-III in a rat model of hypertension induced by N-ω-nitro L-arginine methyl ester (L-NAME). Thirty Sprague Dawley rats were divided into five groups - control (0.9% NaCl, 1 mL for 30 days, oral gavage [o.g.]), hypertensive (40 mg L-NAME /kg, bw for 30 days, intraperitoneal [i.p.]), standard (40 mg L-NAME /kg, bw for  30 days, i.p. + 20 mg Captopril/kg, bw for the last 15 days, o.g.), treatment I (40 mg L-NAME /kg, bw for 30 days, i.p. + mad honey, 12.5 mg GTX-III /kg, bw for the last 15 days, o.g.), and  treatment II ( 40 mg L-NAME /kg, bw for 30 days, i.p.+ <em>R. luteum </em>blossom extract, 155.8 mg GTX-III /kg, bw for the last 15 days, o.g.). In addition to evaluating blood pressure using the tail-cuff method, some biochemical parameters were also measured in serum samples. Moreover, nitric oxide (NO) and glutathione (GSH) concentrations were also analyzed in heart, liver and kidney tissues to measure tissue damage caused by hypertension. The chromatographic analyses revealed GTX-III levels in mad honey and <em>R. luteum </em>of 24.94±0.10 mg/kg and 155.80±0.10 mg/kg, respectively. Both extracts used for animal application had a significant anti-hypertensive effect compared to the control and captopril groups. The systolic and diastolic values of the mad honey and blossom extract groups were 157.97-164.16 and 119.92-120.47, respectively.</p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2023-09-26 16:12:41
 
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http://op.niscair.res.in/index.php/IJTK/article/view/49754
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 22, ##issue.no## 3 (2023): Indian Journal of Traditional Knowledge
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJTK/article/download/49754/465561201