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Predictive value of neoadjuvant chemotherapy on breast cancer subtypes evaluated by DCE-MRI and MRI perfusion parameters

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Field Value
 
Title Predictive value of neoadjuvant chemotherapy on breast cancer subtypes evaluated by DCE-MRI and MRI perfusion parameters
 
Creator Han, Bing
Pan, Shushu
Ruan, Mei
 
Subject Biomarker Ki-67
Estrogen receptors
HER-2 expression
Progesterone receptors
 
Description 807-812
Dynamic contrast enhanced MRI (DCE-MRI) is valuable for
evaluating tumor angiogenesis. We aimed to predict the effects of
neoadjuvant chemotherapy on breast cancer by DCE-MRI
parameters. A total of 162 eligible patients were divided into
response and non-response groups. Ktrans, Kep and Ve before, after
two courses and at the end of neoadjuvant chemotherapy were
compared. ER, PR, HER-2 and Ki-67 expressions in breast cancer
tissues were detected by immunohistochemical staining. DCEMRI
parameters at different ER, PR and HER-2 expression levels
were compared, and their correlations with Ki-67 expression were
analyzed. Ktrans and Kep of response group were lower after two
courses and at the end of neoadjuvant chemotherapy than those
before neoadjuvant chemotherapy (P
 
Date 2023-10-10T05:50:37Z
2023-10-10T05:50:37Z
2023-09
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62717
https://doi.org/10.56042/ijeb.v61i10.5841
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(10) [October 2023]