Ameliorating effects of crude fucoidan extracts from Sargassum spp. obtained from Penghu Islands, Taiwan
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Title |
Ameliorating effects of crude fucoidan extracts from Sargassum spp. obtained from Penghu Islands, Taiwan
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Creator |
Huang, Chun-Yung
wani, Henna Mohiud din Hong, Yong-Han Tsai, Yung-Hsiang Li, Wei-Peng Chiu, Yi-Chen Chang, Jo-Shu Dong, Cheng-Di Patel, Anil Kumar |
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Subject |
Antidiabetic
Anti-inflammation Antioxidant Brown algae Carbohydrate-digesting enzymes Pancreatic cells Reactive oxygen species (ROS) Seaweed |
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Description |
777-788
Sargassum spp., a predominant seaweed speciesin Taiwan's coastal waters, exhibits a broad spectrum of bioactivities. In the present study, we investigated four Sargassum species viz., S. crassifolium, S. siliquosum, S. hemiphyllum,and S. hemiphyllum var. chinense for various bioactivities. From the four species, we made eight fucoidan extracts, namely SC, SCH, SS, SSH, SH, SHH, SHC, and SHCH with or without a compressional puffing pretreatment. The compressionalpuffing process increased the extraction yield of fucoidan and decreased levels of impurities (proteins and polyphenols). Among the eight fucoidans, SS (IC50 DPPH 0.46±0.01 mg/mL; IC50 ABTS•+ 0.09±0.00 mg/mL; FRAP value 67.4±0.9 μmol/g extract, vitamin C equivalent) and SHC (IC50 DPPH 0.53±0.17 mg/mL; IC50 ABTS•+ 0.11±0.00 mg/mL; FRAP value 55.1±0.6 μmol/g extract, vitamin C equivalent) displayed the highest antioxidant activity; SS (36.4±10.1% at 5 mg/mL for 𝛼-amylase; 96.3±0.2% at 1 mg/mL for 𝛼-glucosidase) and SHC (35.0±2.2% at 5 mg/mL for 𝛼-amylase; 96.5±0.2% at 1 mg/mL for 𝛼-glucosidase) showed the strongest 𝛼-amylase and 𝛼-glucosidase inhibitory activities; SH, SHH and SHC had the most potent anti-inflammatory activity; and SHH had a greatest protective effect against damage to pancreatic cells. Hence, SS, SH, SHH, and SHC may be effective health-promoting agents for nutraceutical products. |
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Date |
2023-10-10T05:57:31Z
2023-10-10T05:57:31Z 2023-09 |
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Type |
Article
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Identifier |
0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62721 https://doi.org/10.56042/ijeb.v61i10.1794 |
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Language |
en
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Publisher |
NIScPR-CSIR, India
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Source |
IJEB Vol.61(10) [October 2023]
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