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Levodopa nanoencapsulation in nanostarch as anti-Parkinsonian drugs candidate

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Title Levodopa nanoencapsulation in nanostarch as anti-Parkinsonian drugs candidate
 
Creator Sardjono, Ratnaningsih Eko
Salsabila, Dhea
Gunawan, Ramdhan
Kadarohman, Asep
Anwar, Budiman
Nuraini, Vidia Afina
Erdiwansyah
Mamat, Rizalman
Dara, Fitri
Khairudean, Melati
 
Subject Drug release
Levodopa
Nanoencapsulation
Nanostarch
Parkinson’s disease
 
Description 1056-1060
Parkinson's disease is caused by damage to the dopaminergic nerves in brain. Levodopa has been widely used to treat
Parkinson's disease. The levodopa nano encapsulation aims to improve drug-delivery efficiency thereby increasing the
concentration of released levodopa in the brain. This study aims to obtain the optimum conditions for levodopa nano
encapsulation in nanostarch, the characteristics of levodopa–starch nanocapsules, encapsulation efficiency, and its drugrelease
capabilities. Levodopa nano encapsulation has been carried out by ultrasonication method. Characterization has been
carried out by FTIR, SEM, and TEM. The encapsulation efficiency is measured through changes in levodopa concentrations
using a UV-Vis spectrometer. The drug release profile has been measured at pH 1.2 and 7.4 for 5 hours. The optimum
conditions for levodopa nano encapsulation in nanostarch have been obtained at a mass ratio of nanostarch, maltodextrin and
levodopa of 1:3:1. The SEM and TEM characterization show that levodopa–starch nanocapsules have a spherical
morphology with the particle size ranged from 17.77-49.43 nm. The FTIR characterization show the presence of new peaks
for C=O stretch and N-H bend. The highest encapsulation efficiency has been obtained at 46.11%. Drug release capability
has been obtained by 40.93% in pH 1.2 media and 48.28% in pH 7.4 media for 5 hours of released time.
 
Date 2023-10-17T10:56:58Z
2023-10-17T10:56:58Z
2023-10
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/62777
https://doi.org/10.56042/ijc.v62i10.6184
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.62(10) [October 2023]