Record Details

Genomic insights into the Ixodes scapularis tick vector of Lyme disease

CGSpace

View Archive Info
 
 
Field Value
 
Title Genomic insights into the Ixodes scapularis tick vector of Lyme disease
 
Creator Gulia-Nuss, Monika
Nuss, Andrew B.
Meyer, Jason M.
Sonenshine, Daniel E.
Roe, R. Michael
Waterhouse, Robert M.
Sattelle, David B.
Fuente, José de la
Ribeiro, José Marcos Chaves
Megy, Karine
Thimmapuram, Jyothi
Miller, Jason R.
Walenz, Brian P.
Koren, Sergey
Hostetler, Jessica B.
Thiagarajan, Mathangi
Joardar, Vinita S.
Hannick, Linda I.
Bidwell, Shelby
Hammond, Martin P.
Young, Sarah
Zeng, Qiandong
Abrudan, Jenica L.
Almeida, Francisca C.
Ayllón, Nieves
Bhide, Ketaki
Bissinger, Brooke W.
Bonzon-Kulichenko, Elena
Buckingham, Steven D.
Caffrey, Daniel R.
Caimano, Melissa J.
Croset, Vincent
Driscoll, Timothy
Gilbert, Don
Gillespie, Joseph J.
Giraldo-Calderón, Gloria I.
Grabowski, Jeffrey M.
Jiang, David
Khalil, Sayed M.S.
Kim, Donghun
Kocan, Katherine M.
Koči, Juraj
Kuhn, Richard J.
Kurtti, Timothy J.
Lees, Kristin
Lang, Emma G.
Kennedy, Ryan C.
Kwon, Hyeogsun
Perera, Rushika
Qi, Yumin
Radolf, Justin D.
Sakamoto, Joyce M.
Sánchez-Gracia, Alejandro
Severo, Maiara S.
Silverman, Neal
Šimo, Ladislav
Tojo, Marta
Tornador, Cristian
Zee, Janice P. van
Vázquez, Jesús
Vieira, Filipe G.
Villar, Margarita
Wespiser, Adam R.
Yang, Yunlong
Zhu, Jiwei
Arensburger, Peter
Pietrantonio, Patricia V.
Barker, Stephen C.
Shao, Renfu
Zdobnov, Evgeny M.
Hauser, Frank
Grimmelikhuijzen, Cornelis J.P.
Park, Yoonseong
Rozas, Julio
Benton, Richard
Pedra, Joao H.F.
Nelson, David R.
Unger, Maria F.
Tubio, Jose M.C.
Tu, Zhijian
Robertson, Hugh M.
Shumway, Martin
Sutton, Granger
Wortman, Jennifer R.
Lawson, Daniel
Wikel, Stephen K.
Nene, Vishvanath M.
Fraser, Claire M.
Collins, Frank H.
Birren, Bruce
Nelson, Karen E.
Caler, Elisabet
Hill, Catherine A.
 
Subject ixodes
vector
ticks
 
Description Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing ∼57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick–host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host ‘questing’, prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent.
 
Date 2016-02-09
2023-03-10T14:34:05Z
2023-03-10T14:34:05Z
 
Type Journal Article
 
Identifier Gulia-Nuss, Monika; Nuss, Andrew B.; Meyer, Jason M.; Sonenshine, Daniel E.; Roe, R. Michael; Waterhouse, Robert M.; Sattelle, David B.; Fuente, José de la; Ribeiro, José Marcos Chaves; Megy, Karine; Thimmapuram, Jyothi; Miller, Jason R.; Walenz, Brian P.; Koren, Sergey; Hostetler, Jessica B.; Thiagarajan, Mathangi; Joardar, Vinita S.; Hannick, Linda I.; Bidwell, Shelby; Hammond, Martin P.; Young, Sarah; Zeng, Qiandong; Abrudan, Jenica L.; Almeida, Francisca C.; Ayllón, Nieves; Bhide, Ketaki; Bissinger, Brooke W.; Bonzon-Kulichenko, Elena; Buckingham, Steven D.; Caffrey, Daniel R.; Caimano, Melissa J.; Croset, Vincent; Driscoll, Timothy; Gilbert, Don; Gillespie, Joseph J.; Giraldo-Calderí³n, Gloria I.; Grabowski, Jeffrey M.; Jiang, David; Khalil, Sayed M.S.; Kim, Donghun; Kocan, Katherine M.; Koči, Juraj; Kuhn, Richard J.; Kurtti, Timothy J.; Lees, Kristin; Lang, Emma G.; Kennedy, Ryan C.; Kwon, Hyeogsun; Perera, Rushika; Qi, Yumin; Radolf, Justin D.; Sakamoto, Joyce M.; Sánchez-Gracia, Alejandro; Severo, Maiara S.; Silverman, Neal; Šimo, Ladislav; Tojo, Marta; Tornador, Cristian; Zee, Janice P. van; Vázquez, Jesús; Vieira, Filipe G.; Villar, Margarita; Wespiser, Adam R.; Yang, Yunlong; Zhu, Jiwei; Arensburger, Peter; Pietrantonio, Patricia V.; Barker, Stephen C.; Shao, Renfu; Zdobnov, Evgeny M.; Hauser, Frank; Grimmelikhuijzen, Cornelis J.P.; Park, Yoonseong; Rozas, Julio; Benton, Richard; Pedra, Joao H.F.; Nelson, David R.; Unger, Maria F.; Tubio, Jose M.C.; Tu, Zhijian; Robertson, Hugh M.; Shumway, Martin; Sutton, Granger; Wortman, Jennifer R.; Lawson, Daniel; Wikel, Stephen K.; Nene, Vishvanath M.; Fraser, Claire M.; Collins, Frank H.; Birren, Bruce; Nelson, Karen E.; Caler, Elisabet; Hill, Catherine A. 2016. Genomic insights into the Ixodes scapularis tick vector of Lyme disease. Nature Communications 7:
2041-1723
https://hdl.handle.net/10568/129379
https://doi.org/10.1038/ncomms10507
 
Rights CC-BY-4.0
Open Access
 
Publisher Springer Science and Business Media LLC
 
Source Nature Communications