Genomic insights into the Ixodes scapularis tick vector of Lyme disease
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Title |
Genomic insights into the Ixodes scapularis tick vector of Lyme disease
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Creator |
Gulia-Nuss, Monika
Nuss, Andrew B. Meyer, Jason M. Sonenshine, Daniel E. Roe, R. Michael Waterhouse, Robert M. Sattelle, David B. Fuente, José de la Ribeiro, José Marcos Chaves Megy, Karine Thimmapuram, Jyothi Miller, Jason R. Walenz, Brian P. Koren, Sergey Hostetler, Jessica B. Thiagarajan, Mathangi Joardar, Vinita S. Hannick, Linda I. Bidwell, Shelby Hammond, Martin P. Young, Sarah Zeng, Qiandong Abrudan, Jenica L. Almeida, Francisca C. Ayllón, Nieves Bhide, Ketaki Bissinger, Brooke W. Bonzon-Kulichenko, Elena Buckingham, Steven D. Caffrey, Daniel R. Caimano, Melissa J. Croset, Vincent Driscoll, Timothy Gilbert, Don Gillespie, Joseph J. Giraldo-Calderón, Gloria I. Grabowski, Jeffrey M. Jiang, David Khalil, Sayed M.S. Kim, Donghun Kocan, Katherine M. Koči, Juraj Kuhn, Richard J. Kurtti, Timothy J. Lees, Kristin Lang, Emma G. Kennedy, Ryan C. Kwon, Hyeogsun Perera, Rushika Qi, Yumin Radolf, Justin D. Sakamoto, Joyce M. Sánchez-Gracia, Alejandro Severo, Maiara S. Silverman, Neal Šimo, Ladislav Tojo, Marta Tornador, Cristian Zee, Janice P. van Vázquez, Jesús Vieira, Filipe G. Villar, Margarita Wespiser, Adam R. Yang, Yunlong Zhu, Jiwei Arensburger, Peter Pietrantonio, Patricia V. Barker, Stephen C. Shao, Renfu Zdobnov, Evgeny M. Hauser, Frank Grimmelikhuijzen, Cornelis J.P. Park, Yoonseong Rozas, Julio Benton, Richard Pedra, Joao H.F. Nelson, David R. Unger, Maria F. Tubio, Jose M.C. Tu, Zhijian Robertson, Hugh M. Shumway, Martin Sutton, Granger Wortman, Jennifer R. Lawson, Daniel Wikel, Stephen K. Nene, Vishvanath M. Fraser, Claire M. Collins, Frank H. Birren, Bruce Nelson, Karen E. Caler, Elisabet Hill, Catherine A. |
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Subject |
ixodes
vector ticks |
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Description |
Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing ∼57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick–host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host ‘questing’, prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent.
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Date |
2016-02-09
2023-03-10T14:34:05Z 2023-03-10T14:34:05Z |
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Type |
Journal Article
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Identifier |
Gulia-Nuss, Monika; Nuss, Andrew B.; Meyer, Jason M.; Sonenshine, Daniel E.; Roe, R. Michael; Waterhouse, Robert M.; Sattelle, David B.; Fuente, José de la; Ribeiro, José Marcos Chaves; Megy, Karine; Thimmapuram, Jyothi; Miller, Jason R.; Walenz, Brian P.; Koren, Sergey; Hostetler, Jessica B.; Thiagarajan, Mathangi; Joardar, Vinita S.; Hannick, Linda I.; Bidwell, Shelby; Hammond, Martin P.; Young, Sarah; Zeng, Qiandong; Abrudan, Jenica L.; Almeida, Francisca C.; Ayllón, Nieves; Bhide, Ketaki; Bissinger, Brooke W.; Bonzon-Kulichenko, Elena; Buckingham, Steven D.; Caffrey, Daniel R.; Caimano, Melissa J.; Croset, Vincent; Driscoll, Timothy; Gilbert, Don; Gillespie, Joseph J.; Giraldo-Calderí³n, Gloria I.; Grabowski, Jeffrey M.; Jiang, David; Khalil, Sayed M.S.; Kim, Donghun; Kocan, Katherine M.; Koči, Juraj; Kuhn, Richard J.; Kurtti, Timothy J.; Lees, Kristin; Lang, Emma G.; Kennedy, Ryan C.; Kwon, Hyeogsun; Perera, Rushika; Qi, Yumin; Radolf, Justin D.; Sakamoto, Joyce M.; Sánchez-Gracia, Alejandro; Severo, Maiara S.; Silverman, Neal; Šimo, Ladislav; Tojo, Marta; Tornador, Cristian; Zee, Janice P. van; Vázquez, Jesús; Vieira, Filipe G.; Villar, Margarita; Wespiser, Adam R.; Yang, Yunlong; Zhu, Jiwei; Arensburger, Peter; Pietrantonio, Patricia V.; Barker, Stephen C.; Shao, Renfu; Zdobnov, Evgeny M.; Hauser, Frank; Grimmelikhuijzen, Cornelis J.P.; Park, Yoonseong; Rozas, Julio; Benton, Richard; Pedra, Joao H.F.; Nelson, David R.; Unger, Maria F.; Tubio, Jose M.C.; Tu, Zhijian; Robertson, Hugh M.; Shumway, Martin; Sutton, Granger; Wortman, Jennifer R.; Lawson, Daniel; Wikel, Stephen K.; Nene, Vishvanath M.; Fraser, Claire M.; Collins, Frank H.; Birren, Bruce; Nelson, Karen E.; Caler, Elisabet; Hill, Catherine A. 2016. Genomic insights into the Ixodes scapularis tick vector of Lyme disease. Nature Communications 7:
2041-1723 https://hdl.handle.net/10568/129379 https://doi.org/10.1038/ncomms10507 |
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Rights |
CC-BY-4.0
Open Access |
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Publisher |
Springer Science and Business Media LLC
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Source |
Nature Communications
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