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Bioactivity of leaf and bark extractives of Prosopis africana (Guill., Perrott. and Rich.) Taub. against some multidrug-resistant microbes

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Title Bioactivity of leaf and bark extractives of Prosopis africana (Guill., Perrott. and Rich.) Taub. against some multidrug-resistant microbes
 
Creator N. A, Sadiku
I. I, Anibijuwon
T. O, Amusa
E. T, Awolola
 
Subject Gram-negative and positive
MBC
Phytochemical
MFC
MIC
Susceptibility test
 
Description 470-481
The aqueous, methanolic, ethanolic and n-Hexane leaf and bark of P. africana extracts were tested for antimicrobial
activity against five clinical pathogens: Acinetobacter baumanii, Escherichia coli 25922, Escherichia coli ESBL, Methicillin-
Resistant Staphylococcus aureus, and Candida albicans ELI. Antimicrobial sensitivity test was carried out using the agar well
diffusion method at a stock and varying concentrations of 500, 1000 and 1500 mg/mL. Results indicated that
n-hexane leaf and bark extracts could not inhibit the organisms. Aqueous leaf extracts inhibited A. baumanii, MRSA, E. coli
ESBL and E. coli 25922, while aqueous bark extract inhibited A. baumanii, MRSA, E. coli 25922, C. albicans ELI. Methanolic
leaf extracts inhibited A. baumanii, MRSA, E. coli ESBL, while Methanolic bark extracts inhibited A. baumanii, MRSA, E. coli
ESBL, E. coli 25922, C. albicans ELI. Ethanolic bark extracts inhibited A. baumanii, MRSA, E. coli ESBL, E. coli 25922,
C. albicans ELI. The Minimum Inhibitory Concentration of the extracts for leaf and bark ranged from 1500 mg/mL – 23.43
mg/mL. Minimum Bactericidal Concentration was observed in aqueous leaf extracts against E. coli 25922 at 1500
concentration. Antibiotics susceptibility test indicated multidrug resistance by the test organisms with only Ofloxacin,
Gentamycin, Ceftazidime and Nitrofurantoin eliciting inhibitory activity against A. baumanii, E. coli ESBL and E. coli 25922,
respectively. Preliminary phytochemical screening revealed that P. africana leaf and bark extractives contained beneficial
phytochemicals responsible for their high bioactivity against the selected clinical isolates.
 
Date 2023-10-26T06:45:26Z
2023-10-26T06:45:26Z
2023-09
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/62800
https://doi.org/10.56042/ijnpr.v14i3.4617
 
Language en
 
Relation Int. cl. (2021.01)- A61K 36/00, A61K 36/48, A61K 127/00, A61K 129/00, A61P 31/00
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.14(3) [September 2023]