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Chemical composition and antibacterial activity of the essential oil and extract from Mentha longifolia against Helicobacter pylori

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Title Chemical composition and antibacterial activity of the essential oil and extract from Mentha longifolia against Helicobacter pylori
 
Creator Kacho, Hanie Ahmadpour
Kazemi, Sohrab
Farhadi, Pezhman
 
Subject Antimicrobial activity
Chemical composition
Essential oil and extract
Helicobacter pylori
Mentha longifolia
 
Description 458-463
Helicobacter pylori infection is prevalent, affecting almost half of the world's population. Eradicating H. pylori with
antibiotics is a global challenge due to medication resistance. Developing new treatment regimens is one of the most
important tactics for combating medication resistance. Herbal treatments have attracted a lot of interest recently among the
many H. pylori infection adjunct therapies. M. longifolia is an edible plant found in northern Iran; its leaves have
traditionally been used to cure gastrointestinal ailments. This study aims to determine the chemical composition of the
essential oil (EO) derived from M. longifolia leaves using GC-MS and assess the anti-H. pylori activity of the EO and
methanolic extract using the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC)
methods. Results showed that the main components of M. longifolia EO were cis-Piperitenone oxide (67.064%),
piperitenone oxide (9.135%), L-Menthone (5.745%), Trans Caryophyllene (5.271%) and Eucalyptol (3.524%). M. longifolia
EO exhibited the greatest anti-H. pylori activity (MIC=187 μg/mL), while the methanolic extract was (MIC=1500 μg/mL).
The phytochemicals studied in this study have the potential to be utilized as adjuvant therapy with standard antibiotics
against H. pylori.
 
Date 2023-10-26T06:52:53Z
2023-10-26T06:52:53Z
2023-09
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/62802
https://doi.org/10.56042/ijnpr.v14i3.4044
 
Language en
 
Relation Int. cl. (2021.01)−A61K 36/00, A61K 36/53, A61P 31/00
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.14(3) [September 2023]