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Antifungal activity, phytochemical analysis and mode of action of Atrichum undulatum (Hedw.) P. Beauv.

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Title Antifungal activity, phytochemical analysis and mode of action of Atrichum undulatum (Hedw.) P. Beauv.
 
Creator Kaur, Satvir
Kapila, Sunita
Sabharwal, Hiteshi
 
Subject Antifungal activity
Atrichum
Candida
Flow cytometry
Microscopy
 
Description 451-457
In the present study, the antifungal activity of a West Himalayan bryophyte Atrichum undulatum in different solvents
(butanol, ethanol, methanol and aqueous) has been evaluated by agar well diffusion assay against six fungal strains
(Candida albicans, C. glabrata, C. tropicalis, C. parapsilosis, Issatchenkia orientalis and Kluyveromyces marxianus).
Among all the extracts, butanol extract showed potent antifungal activity against I. orientalis, K. marxianus, C. parapsilosis
and C. tropicalis followed by ethanol and methanol extract. Fungal cells treated with butanol extract showed cell wall
damage under scanning electron microscopy and confocal microscopy. GC-MS and FTIR analysis showed the presence of
bioactive compounds which act as antimicrobial agents. The results support the traditional use of A. undulatum as an
antimicrobial agent. The present research records for the first time the morphological alterations of fungal cells by the
butanol extract of A. undulatum alone and synergistically with the antibiotic Amphotericin B (Amp B).
 
Date 2023-10-26T07:05:34Z
2023-10-26T07:05:34Z
2023-09
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/62803
https://doi.org/10.56042/ijnpr.v14i3.4696
 
Language en
 
Relation Int. cl. (2021.01) – A61K 36/00
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.14(3) [September 2023]