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An investigation on antioxidant and anti-arthritic activity of Rheum nobile Hook.f. & Thomson from Sikkim Himalayan region

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Title An investigation on antioxidant and anti-arthritic activity of Rheum nobile Hook.f. & Thomson from Sikkim Himalayan region
 
Creator Subba, Aita Rani
Rai, Santosh Kumar
Gurung, Jiwan
Singh, Bisu
 
Subject Anti-arthritic
Antioxidant
Phytochemicals
Rheum nobile
Sikkim Himalayan region
 
Description 434-443
The present study was carried out to determine the phytochemical constituents, physicochemical values, antioxidant
activity and in-vitro anti-inflammatory activity of Rheum nobile Hook.f & Thomson according to the standard
pharmacopoeial method, which is traditionally used by the indigenous communities of the Sikkim Himalayan region for the
treatment of rheumatoid arthritis. The phytochemical investigation revealed the presence of various secondary metabolites
such as flavonoids, tannins, phenols, steroids, phlobatannins, saponins, anthraquinones and glycosides. The in-vitro antiinflammatory
activity of the plant extract assessed by HRBC membrane stabilisation and protein denaturation methods is
found to effectively inhibit HRBC haemolysis and protein denaturation in a dose-dependent manner. The present finding
provides evidence for the antioxidant and anti-inflammatory activity of the plant extract, which approves the traditional
statements of Rheum nobile as an anti-arthritic agent.
 
Date 2023-10-26T07:10:25Z
2023-10-26T07:10:25Z
2023-09
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/62805
https://doi.org/10.56042/ijnpr.v14i3.4786
 
Language en
 
Relation Int. cl. (2021.01)−A61K 36/00, A61K 125/00, A61P 29/00, A61P 39/00
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.14(3) [September 2023]