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Assessment of in vitro anti-inflammatory, hemostatic, antimicrobial, photoprotective and antioxidant activities of the Algerian species Suaeda monodiana

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Title Assessment of in vitro anti-inflammatory, hemostatic, antimicrobial, photoprotective and antioxidant activities of the Algerian species Suaeda monodiana
 
Creator Mouffouk, Sara
Mouffouk, Soumia
Mouffouk, Chaima
Haba, Hamada
 
Subject Anti-inflammatory
Antimicrobial
Antioxidant
Hemostatic
Photoprotective
Suaeda monodiana
 
Description 425-433
The efficient cutaneous wound healing process constitutes a critical challenge for clinical and fundamental research. Indeed, agents that prevent bacterial infections, the excessive production of free radicals, and inflammation may enhance wound healing. In this context, the biological activities of the methanolic extract prepared from the species Suaeda monodiana Maire were assessed. The antioxidant activity was tested by five different methods, and the sun protection factor was measured. The hemostatic activity was evaluated by determining plasma re-calcification time, and the anti-inflammatory effect was carried out by heat-inducing hemolysis and albumin denaturation tests. The antimicrobial activity was evaluated by the agar disk diffusion assay against seven strains. As a result, the tested extract has a rich chemical composition and possesses interesting photoprotective (SPF at 46.49±0.05) and antioxidant activities. This extract showed the ability to inhibit protein denaturation (IC50 at 1.22±0.8 mg/mL) and to protect the erythrocytes membrane (IC50 at 2.39±0.3 mg/mL). Moreover, the Methanol extract significantly shortens the clotting time and inhibits the growth of all the tested strains with minimum inhibitory concentrations ranging between 31.25 to 250 μg/mL. Furthermore, due to its pharmacological properties, S. monodiana species could be used in pharmaceutical formulations for the treatment of skin diseases.
 
Date 2023-10-26T07:15:38Z
2023-10-26T07:15:38Z
2023-09
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/62806
https://doi.org/10.56042/ijnpr.v14i3.4612
 
Language en
 
Relation Int. cl. (2021.01)- A61K 36/00, A61P 7/00, A61P 29/00, A61P 31/00, A61P 39/00
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.14(3) [September 2023]