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Screening of anticancer potential of leaf aqueous extract from Pulicaria incisa growing wild in Palestine

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Title Screening of anticancer potential of leaf aqueous extract from Pulicaria incisa growing wild in Palestine
 
Creator Abdallah, Lubna
Omar, Ghadeer
Khdeer, Shaima Abu
Heeh, Hadeel
Khateeb, Deena
Salameh, Noor
 
Subject Anticancer
Cytostatic
Cytotoxic
Extract
Pulicaria incisa
 
Description 402-408
The anticancer potential of Pulicaria incisa aqueous extract was estimated by measuring its cytotoxic and cytostatic effect
on human cervical cancer (Hela), human colorectal adenocarcinoma (HT-29), and skin melanoma cancer (B16–F1) cell lines.
This effect was investigated by the exposure of cancer cell lines to the aqueous extract of P. incisa at different concentrations
(5, 2.5, 1.25, 0.625, 0.3215 mg/mL) for 24 and 72 hours. The results showed that the studied extract inhibited the growth of the
various cell lines, eventually leading to cell death, as shown by both MTT and LDH assays. The extract of P. incisa displayed
the strongest cytotoxic effect against HT-29 cells at high concentrations at which viability was nearly zero %, while the
strongest cytostatic effect of the prepared extract was on the B16–F1 cells at high concentrations. Nonetheless, P. incisa extract
gave exciting results on Hela cells with a cytotoxic effect at high concentrations and a cytostatic effect at low concentrations. In
conclusion, the cytotoxic and cytostatic effect of P. incisa aqueous extract against the three cell lines is due to the presence of
several phytochemicals. So, using this plant species as a source for antitumor agents alone or in combination with other agents
for cancer treatment is proposed.
 
Date 2023-10-26T07:21:36Z
2023-10-26T07:21:36Z
2023-09
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/62808
https://doi.org/10.56042/ijnpr.v14i3.5404
 
Language en
 
Relation Int. cl. (2021.01)- A61K 36/00, A61K 36/28, A61P 35/00
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.14(3) [September 2023]