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Phytochemical screening and anti-hyperglycemic effect of Jatropha multifida L. ethanol extract and its fraction on a high-fat diet and Streptozotocin-induced diabetic rats

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Title Phytochemical screening and anti-hyperglycemic effect of Jatropha multifida L. ethanol extract and its fraction on a high-fat diet and Streptozotocin-induced diabetic rats
 
Creator Tripathi, Suchita
Mukerjee, Alok
Gupta, Nishi
 
Subject Blood sugar level
Diabetes mellitus
High fat diet
Jatropha multifida
Streptozotocin
 
Description 391-401
Jatropha multifida L. is a plant traditionally recognized for its medicinal properties. This plant has been reported to possess anti-microbial, anti-oxidative, wound healing and anti-inflammatory properties. The study aimed to evaluate the anti-diabetic potentials of J. multifida. The study deals with the extraction of the leaves of the plant by using 50% ethanol followed by fractionation of the ethanol extract obtained. Various physicochemical parameters and phytochemical analyses were done by TLC and HPTLC. Phytochemical analysis of the extract and its fraction indicated high concentrations of flavonoids, phenolic acid and saponins. The effects of the 50% ethanol extract of J. multifida leaves, and its hexane fraction were investigated in high-fat diet and Streptozotocin-induced diabetic rats. At the end of the treatment, the reduction in blood glucose level in rats treated with ethanol extract at a dose of 400 mg/kg was found to be 117.5±1.7 and hexane fraction at 200 mg/kg was found to be 105±2.5. A significant improvement in lipid profile and liver abnormalities of the rats was observed. The result of the present study is also justified by histopathological examinations of the pancreas and liver. Therefore, the current study proved that both the ethanolic extract of J. multifida and its hexane fraction possess bioactive constituents that could be responsible for the anti-diabetic properties. Out of the two, maximum improvement was seen using hexane fraction at 200 mg/kg. This may be due to the active phytoconstituents isolated from the fraction of the 50% ethanolic extract of the leaves.
 
Date 2023-10-26T07:23:35Z
2023-10-26T07:23:35Z
2023-09
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/62809
https://doi.org/10.56042/ijnpr.v14i3.4620
 
Language en
 
Relation Int. cl. (2021.01)− A61K 36/00, A61K 127/00, A61P 3/00, A61P 3/10
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.14(3) [September 2023]