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Investigation of antidiabetic effect of Ferula assa-foetida oleo gum resin and its essential oil on ovariectomised diabetic rats

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Title Investigation of antidiabetic effect of Ferula assa-foetida oleo gum resin and its essential oil on ovariectomised diabetic rats
 
Creator Ghalenoei, Jalil Alizadeh
Sirizi, Mohammad Amin Ghafari
Yadegari, Maryam
Javidmehr, Davoud
Nodoushan, Mahdieh Jafari
Bagheri, Seyyed Majid
 
Subject Diabetes mellitus
Essential oil
Ferula assa-foetida
Ovariectomised rats
 
Description 384-390
The aim of the present study was to evaluate the hypoglycemic activity of asafoetida and essential oil of asafoetida (EOA) in ovariectomised (OVX) diabetic rats. Twenty-four female rats were divided into four groups consisting of 6 rats in each group. OVX Control, OVX diabetic, OVX diabetic and asafoetida (25 mg/kg), OVX diabetic and EOA 25 μL/kg. Fasting Blood glucose, lipid profiles and liver indices were measured, and liver and kidney histopathology was investigated. Urine volume, urea, creatinine, and microalbumin were measured. The neuropathic damage was assessed by the hot plate method. The results showed that only in the asafoetida group the blood sugar, ALT and AST levels decreased significantly. Consumption of food, water, and body weight also decreased in the asafoetida grouponly. Also, regarding histology, relative improvement was observed in kidney and liver tissue in the asafoetida group. A significant decrease in urine volume and improvement in creatinine, urea and microalbumin concentrations, as well as improvement in hot plate test response time, were observed in both treatment groups. It can be concluded that asafoetida is effective in treating diabetes, but its essential oil has no effective activity on diabetes mellitus.
 
Date 2023-10-26T07:25:58Z
2023-10-26T07:25:58Z
2023-09
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/62810
https://doi.org/10.56042/ijnpr.v14i3.4627
 
Language en
 
Relation Int. cl. (2021.01)- A61K 36/00, A61K 36/23, A61P 3/00, A61P 3/10
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.14(3) [September 2023]