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Foeniculum vulgare Mill.: Chemical composition, in vitro anti-diabetic and anti-inflammatory assessment

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Title Foeniculum vulgare Mill.: Chemical composition, in vitro anti-diabetic and anti-inflammatory assessment
 
Creator Mehra, Nisha
Tamta, Garima
Nand, Viveka
 
Subject Anti-diabetic
Anti-inflammatory
Apiaceae
Fennel
Foeniculum vulgare Mill
GC-MS
 
Description 372-383
Fennel is a culinary spice of the Apiaceae family and is traditionally used as medicine for a wide range of ailments
accompanied by digestive, respiratory, gastrointestinal and hormonal imbalance systems. Fennel has an anti-inflammation
property to relieve normal cough/cold and abdominal pain. This research was assessed to analyse the chemical composition and
biological activities in hexane and methanol extract of fennel seeds collected from the Terai region in the Uttarakhand state.
Chemical composition was examined in polar (methanol) and non-polar (hexane) extracts of fennel seeds using GC-MS
technique. An in vitro anti-diabetic and anti-inflammatory assay was observed in fennel extract. A statistical approach was done
by cluster analysis in fennel seeds. D-arabitol (29.51%), Octadecadienoic acid (25.80%), Methyl pyrrolidine (23.41%),
Guanosine (15.73%), Xanthine riboside (16.10%) were major components identified in methanol extract of fennel.
Octadecenoic acid, palmitic acid, oleamide, trimesic acid, and linoleic acid were observed to major in the range of 79.43, 12.61,
32.76, 17.66, and 35.18 in the hexane extract of fennel, respectively. The highest α-amylase and α-glucosidase inhibition
potential were observed in the hexane extract of FNL-125 (IC50=227.77±0.64 μg/mL) and FNL-120 (IC50=230.02±0.62
μg/mL), respectively. Hexane extract of FNL-125 (IB50= 676.44±0.96 μg/mL) exhibits superior anti-inflammatory activity.
These fennel seeds have effective biological activities in hexane extract, suggesting their use for drug purposes. A statistical
approach was undertaken with cluster analysis in fennel seeds that could be used to develop a new variety of fennel that
possesses prominent chemical constituents with effective pharmacological activities and to be used in pharma industries.
 
Date 2023-10-26T07:28:00Z
2023-10-26T07:28:00Z
2023-09
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/62811
https://doi.org/10.56042/ijnpr.v14i3.4598
 
Language en
 
Relation Int. cl. (2021.01)−A61K 36/00, A61K 131/00, A61P 3/00, A61P 3/10, A61P 29/00
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.14(3) [September 2023]