Record Details

Evaluation of bioactive potentials in the crude flavonoid fraction from the leaves of Butea monosperma (Lam.)Taub. in vitro and in vivo in experimental models

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Evaluation of bioactive potentials in the crude flavonoid fraction from the leaves of Butea monosperma (Lam.)Taub. in vitro and in vivo in experimental models
 
Creator Bala, Rajni
Mehta, Sakshi
Roy, Vikas C
Roy, Ram C
Roy, Sharda
Singh, Jaspreet
 
Subject Anticonvulsant
Dhak
Epilepsy
Antioxidants
Forest flame
Maximal electroshock
Oxidative stress
Palash
Pentylene tetrazole
Sacre tree
Seizures
 
Description 893-898
Oxidative stress is responsible for the advent of seizure hence, antioxidants are used for the treatment neurodegenerative ailments such as epilepsy. The Sacred tree, Butea monosperma (Lam.)Taub. is known to possess several medicinal properties due to the presence of steroids, alkaloids, triterpenoids, polyphenols, flavonoids, tannins and glycosides, particularly in the leaves. In the present study, we evaluated the bioactive potentials in the isolated crude flavonoid fraction (FF) from its leaves. FF was isolated by successive methanol extract method and was evaluated for antioxidant and anticonvulsant activities in vitro and in vivo. For in vivo study, 25 healthy Wistar albino rats were employed in five groups: Gr.I: control; Gr. II: standard group receiving phenytoin sodium; and Gr. III-V: test groups receiving oral doses of FF i.e., 50, 100 and 200 mg/kg, respectively. In vitro data showed concentration dependent antioxidant activity (88.86±0.006%), reducing power activity (0.694±0.002%) and nitric oxide scavenging activity (87.98±0.013%). In vivo, a significant depression in the phases and percentage incidence of convulsions was observed in the maximal electroshock model in a dose-dependent manner. The pentylene tetrazole-induced seizure model also depicted a significant (P ≤0.001) decrease in the latency of convulsions and an increase in the percentage protection against the convulsions in a dose-dependent manner. Our findings suggest antioxidant and anticonvulsant potential of FF obtained from Butea monosperma leaves.
 
Date 2023-11-01T07:10:05Z
2023-11-01T07:10:05Z
2023-11
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62845
https://doi.org/10.56042/ijeb.v61i11.1533
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(11) [November 2023]