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Anti-inflammatory effect of ethanolic extract of Ocimum basilicum L. in the healing process of incisional wounds in mice

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Title Anti-inflammatory effect of ethanolic extract of Ocimum basilicum L. in the healing process of incisional wounds in mice
 
Creator Costa, Renan Araujo
Dias, Karine Sthéfany Serpa Amaral
Rabelo, Geniane Viana
Ferreira, Elisângela Elduina
Ferreira, Letícia Marcelle
Carvalho, Bianca Andrade
Silva, Izabela Caputo Assis
Costa, Raquel Alves
Lima, Luciana Alves Rodrigues dos Santos
Pinto, Flávia Carmo Horta
 
Subject Basil
Inflammation
Wound healing
 
Description 881-887
Maintaining the structural and functional integrity of the skin is critical to ensure body homeostasis. After damage, a series of cellular and molecular events occurs in this structure in order to repair the injured tissue. Imbalances in one or more repair steps are commonly related to difficulties in proceeding with healing. This has driven the search for natural molecules from plants to improve the repair process that is economical with less side effects. In this context, the common medicinal herb, Ocimum basilicum L., used globally from cooking to practices in folk medicine, has in its phytoconstitution substances with different actions such as anti-inflammatory, antioxidant, antimicrobial. Therefore, in the present study, we have evaluated the anti-inflammatory effect of intraperitoneal treatment with ethanolic extract of O. basilicum (EEOB) on wound healing in mice. Incisional wounds were induced in mice, they were divided according to treatment period and group, n=6, and received EEOB intraperitoneally (i.p.) at 150 mg/kg daily or saline solution for 5 or 7 days. At the end of this period, the animals were euthanized and the lesions underwent histopathological processing and analysis. In animals treated with EEOB injection, there was a decrease in the number of leukocytes at 5 days and mast cells at 7 days post-injury compared to the control. The observed anti-inflammatory action can be attributed to the phenolic compounds and their individual or synergistic effects on the healing process.
 
Date 2023-11-01T07:15:09Z
2023-11-01T07:15:09Z
2023-11
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62847
https://doi.org/10.56042/ijeb.v61i11.1908
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(11) [November 2023]