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Abelmoschus esculentus (L.) Moench seed extract alleviates acute acetaminophen induced liver damage in rats

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Title Abelmoschus esculentus (L.) Moench seed extract alleviates acute acetaminophen induced liver damage in rats
 
Creator Kocabey, Huseyin
Bekdas, Mervan
Cetinkaya, Ayhan
Duzcu, Selma Erdogan
Alisik, Murat
Dincel, Gokce Kaya
Turel, Idris
 
Subject N-acetyl cysteine (NAC)
Hepatic injury
Interleukin-10
Okra
Paracetamol
Reactive oxygen species (ROS)
Thiol
 
Description 852-860
Acetaminophen (N-acetyl-p-aminophenol, APAP), commonly called the ‘paracetamol’, is one of the most regularly utilized medicines, particularly in children. When administered at the recommended doses, it is a safe medication. However, oxidative stress and inflammation caused by exposure to toxic doses lead to centrilobular hepatic necrosis. N-acetylcysteine (NAC) is utilized in the therapy, however it has potential adverse effects. On the other hand, it is known that the seeds of the common vegetable Okra, Abelmoschus esculentus (AE), a herbal product, possess antioxidant and anti-inflammatory qualities. In the present study, we explored whether AE can be used as an alternative to standard NAC therapy without any adverse effect in the treatment of acute APAP induced liver injury. Forty male Wistar rats were placed into five groups: Control, AE, APAP, APAP+AE and APAP+AE+NAC groups. Antioxidants such as native thiol and total thiol were found rised in the APAP group by adding AE (p =0.043 and p =0.028, respectively). Anti-inflammatory indicator IL-10 was also found increased, while marker ALT, which is a sign of hepatotoxicity, got decreased (P=0.005 and P
 
Date 2023-11-01T08:41:05Z
2023-11-01T08:41:05Z
2023-11
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62850
https://doi.org/10.56042/ijeb.v61i11.1326
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(11) [November 2023]