Abelmoschus esculentus (L.) Moench seed extract alleviates acute acetaminophen induced liver damage in rats
NOPR - NISCAIR Online Periodicals Repository
View Archive InfoField | Value | |
Title |
Abelmoschus esculentus (L.) Moench seed extract alleviates acute acetaminophen induced liver damage in rats
|
|
Creator |
Kocabey, Huseyin
Bekdas, Mervan Cetinkaya, Ayhan Duzcu, Selma Erdogan Alisik, Murat Dincel, Gokce Kaya Turel, Idris |
|
Subject |
N-acetyl cysteine (NAC)
Hepatic injury Interleukin-10 Okra Paracetamol Reactive oxygen species (ROS) Thiol |
|
Description |
852-860
Acetaminophen (N-acetyl-p-aminophenol, APAP), commonly called the ‘paracetamol’, is one of the most regularly utilized medicines, particularly in children. When administered at the recommended doses, it is a safe medication. However, oxidative stress and inflammation caused by exposure to toxic doses lead to centrilobular hepatic necrosis. N-acetylcysteine (NAC) is utilized in the therapy, however it has potential adverse effects. On the other hand, it is known that the seeds of the common vegetable Okra, Abelmoschus esculentus (AE), a herbal product, possess antioxidant and anti-inflammatory qualities. In the present study, we explored whether AE can be used as an alternative to standard NAC therapy without any adverse effect in the treatment of acute APAP induced liver injury. Forty male Wistar rats were placed into five groups: Control, AE, APAP, APAP+AE and APAP+AE+NAC groups. Antioxidants such as native thiol and total thiol were found rised in the APAP group by adding AE (p =0.043 and p =0.028, respectively). Anti-inflammatory indicator IL-10 was also found increased, while marker ALT, which is a sign of hepatotoxicity, got decreased (P=0.005 and P |
|
Date |
2023-11-01T08:41:05Z
2023-11-01T08:41:05Z 2023-11 |
|
Type |
Article
|
|
Identifier |
0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62850 https://doi.org/10.56042/ijeb.v61i11.1326 |
|
Language |
en
|
|
Publisher |
NIScPR-CSIR, India
|
|
Source |
IJEB Vol.61(11) [November 2023]
|
|