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Hematopoietic and hepatoprotective activity of Basella alba L. fruit extract in experimental animal model

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Title Hematopoietic and hepatoprotective activity of Basella alba L. fruit extract in experimental animal model
 
Creator Ghosh, Sourav
Gomes, Aparna
Gomes, Antony
 
Subject Anemia
Antioxidants
Cytokines
Indian spinach
Iron deficiency
Malabar spinach
 
Description 843-851
Basella alba L. fruit extract (BAFE) has been used in rural eastern India by the traditional practitioners to treat anemia during pregnancy. In the present study, we have demostrated the hematopoietic and hepatoprotective activity of BAFE in animal model. Male Swiss albino rats were divided into: Gr. I, sham control; Gr. II, disease control (anemia or hepatotoxicity); Gr. III, standard drug treated; Gr. IV, BAFE treated (low dose); and Gr.V, BAFE treated (high dose). Anemia was induced in animals through blood loss at regular intervals and hematological, cytokine, antioxidant parameters and RBC morphology were done. Hepatotoxicity was induced in animals by CCl4 (1 mL/kg/p.o.) and serum biochemistry, cytokine, antioxidant parameters and histology were done. There was a significant improvement of hematology (Hb, TC of RBC, TC of WBC, hematocrit, serum iron, TIBC), cytokine (IL 1β), antioxidant (SOD, catalase, LPO, GSH) and RBC morphology in BAFE treated animals when compared to Gr. II animals. Significant improvement in biochemical (AST, ALT, γGT, ACP, ALP and total bilirubin), cytokine (IL 1β, IL 4, IL 12, IL 17, cathepsin K and TNF α), antioxidant (SOD, catalase, LPO and GSH) and liver histology were observed in BAFE treated animals when compared to Gr. II animals. The present study confirmed the hematopoietic and hepatoprotective activity of BAFE in animal model and warrants further studies.
 
Date 2023-11-01T08:45:20Z
2023-11-01T08:45:20Z
2023-11
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62851
https://doi.org/10.56042/ijeb.v61i11.3650
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(11) [November 2023]