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Antioxidant and Anticancer Activity of Rhynchosia rufescens (Willd.) DC.

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Title Antioxidant and Anticancer Activity of Rhynchosia rufescens (Willd.) DC.
 
Creator P, Vishnu Mohan Reddy
Yadav, Pulala Raghuveer
Ratnam, K Venkata
 
Subject Antibacterial
Essential oil composition
Flavonoid
HCT-116 cell lines
Phenolic
 
Description 857-867
The present study deals with the chemical composition, antioxidant, antimicrobial and anticancer efficacy of
Rhynchosia rufescens (RR) leaf methanol (RRME), ethyl acetate (RREAE) and petroleum ether (RRPE) extracts.
Preliminary phytochemical results revealed that alkaloids, coumarins, flavonoids, volatile oils, fatty acids, and phenols were
present in the test extracts. Gas chromatographic analysis of RRPE revealed the identification of 25 volatile compounds. The
oil contains monoterpenes (9.6%) and fatty acids (6.12%). The major components of the oil are beta- copaene (32.06%),
cyclofenchene (16.53%), beta- pinene (5.69%), 3-carene (3.48%) and sabinene (3.22%). Quantitative estimation of total
phenols (TPC) and flavonoids (TFC) indicated that TPC ranged from 8.99 ±1.00 to 60.00±1.15 mg GAE/g dry weight and
TFC was between 4.98±0.08 to 20.4±0.50 mg QE/ g dry weight respectively. Methanol extract showed the highest
phosphomolybdenum dependent antioxidant capacity, while ethyl acetate extracts strongly inhibited DPPH and hydroxyl
radicals. Anticancer study results revealed that ethyl acetate extract enhanced caspase-3 mediated DNA fragmentation in
HCT – 116 cell lines than standard cisplatin. In conclusion, R. rufescens extracts showed potent antioxidant, antibacterial
activity and potential anticancer activity in HCT-116 cell lines. The observations of this study indicated that R. rufescens
extracts are a rich source of natural antioxidants and anticancer components.
 
Date 2023-11-10T07:31:12Z
2023-11-10T07:31:12Z
2023-11
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/62892
https://doi.org/10.56042/ijbb.v60i11.717
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJBB Vol.60(11) [November 2023]