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Genomic, morphological, and biochemical analyses of a multi-metal resistant but multi-drug susceptible strain of Bordetella petrii from hospital soil.

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Title Genomic, morphological, and biochemical analyses of a multi-metal resistant but multi-drug susceptible strain of Bordetella petrii from hospital soil.
Not Available
 
Creator U. Halder
R. Biswas
A. Kabiraj
R. Deora
M. Let
R.K. Roy
A. Chitikineni
K. Majhi
S. Sarkar
B. Dutta
A. Laha
A. Datta
D. Khan
R.K. Varshney
D. Saha
S. Chattopadhyay
R. Bandopadhyay
 
Subject Morphological analysis
Biochemical analysis
Genomic analysis
metal resistant
drug resistant
hospital soil isolate
B. petrii
 
Description Not Available
Contamination of soil by antibiotics and heavy metals originating from hospital facilities has emerged as a major cause for the development of resistant microbes. We collected soil samples surrounding a hospital effluent and measured the resistance of bacterial isolates against multiple antibiotics and heavy metals. One strain BMCSI 3 was found to be sensitive to all tested antibiotics. However, it was resistant to many heavy metals and metalloids like cadmium, chromium, copper, mercury, arsenic, and others. This strain was motile and potentially spore-forming. Whole-genome shotgun assembly of BMCSI 3 produced 4.95 Mb genome with 4,638 protein-coding genes. The taxonomic and phylogenetic analysis revealed it, to be a Bordetella petrii strain. Multiple genomic islands carrying mobile genetic elements; coding for heavy metal resistant genes, response regulators or transcription factors, transporters, and multi-drug efflux pumps were identified from the genome. A comparative genomic analysis of BMCSI 3 with annotated genomes of other free-living B. petrii revealed the presence of multiple transposable elements and several genes involved in stress response and metabolism. This study provides insights into how genomic reorganization and plasticity results in evolution of heavy metals resistance by acquiring genes from its natural environment.
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Date 2023-10-26T14:42:12Z
2023-10-26T14:42:12Z
2022-05-19
 
Type Journal
 
Identifier Haldar, U., Biswas, R.,…..Saha, D., et al. (2022). Genomic, morphological, and biochemical analyses of a multi-metal resistant but multi-drug susceptible strain of Bordetella petrii from hospital soil. Scientific Reports. 12(1): 8439. https://doi.org/10.1038/s41598-022-12435-7
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http://krishi.icar.gov.in/jspui/handle/123456789/80838
 
Language English
 
Relation Not Available;
 
Publisher Nature Springer