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Proteoglycans in breast cancer, identification and characterization by LC-MS/MS assisted proteomics approach: A review

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Title Proteoglycans in breast cancer, identification and characterization by LC-MS/MS assisted proteomics approach: A review
Not Available
 
Creator Ajeeshkumar, K. K.
Ankita Sahu
Astha Singh
Ravindran, N. A.
Chatterjee, N. S.
Suseela Mathew
Saurabh Verma
 
Subject breast cancer
LC-MS/MS
proteoglycans biomarker
proteomics
 
Description Not Available
Purpose
Proteoglycans (PGs) are negatively charged macromolecules containing a core protein and single or several glycosaminoglycan chains attached by covalent bond. They are distributed in all tissues, including extracellular matrix (ECM), cell surface, and basement membrane. They are involved in major pathways and cell signalling cascades which modulate several vital physiological functions of the body. They have also emerged as a target molecule for cancer treatment and as possible biomarkers for early cancer detection. Among cancers, breast cancer is a highly invasive and heterogenous type and has become the major cause of mortality especially among women. So, this review revisits the studies on PGs characterization in breast cancer using LC-MS/MS-based proteomics approach, which will be further helpful for identification of potential PGs-based biomarkers or therapeutic targets.

Experimental design
There is a lack of comprehensive knowledge on the use of LC-MS/MS-based proteomics approaches to identify and characterize PGs in breast cancer.

Results
LC-MS/MS assisted PGs characterization in breast cancer revealed the vital PGs in breast cancer invasion and progression. In addition, comprehensive profiling and characterization of PGs in breast cancer are efficiently carried out by this approach.

Conclusions
Proteomics techniques including LC-MS/MS-based identification of proteoglycans is effectively carried out in breast cancer research. Identification of expression at different stages of breast cancer is a major challenge, and LC-MS/MS-based profiling of PGs can boost novel strategies to treat breast cancer, which involve targeting PGs, and also aid early diagnosis using PGs as biomarkers.
Not Available
 
Date 2023-10-25T14:16:51Z
2023-10-25T14:16:51Z
2023-07
 
Type Research Paper
 
Identifier Ajeeshkumar, K. K., Ankita Sahu, Astha Singh, Ravindran, N. A., Chatterjee, N. S., Suseela Mathew and Saurabh Verma (2023) Proteoglycans in breast cancer, identification and characterization by LC-MS/MS assisted proteomics approach: A review. Proteom- Clin. Appl. 17: 2200046.
1862-8346
http://krishi.icar.gov.in/jspui/handle/123456789/80810
 
Language English
 
Relation Not Available;
 
Publisher Wiley