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Prevention of dabigatran ınduced cytotoxicity by N-acetyl cysteine: An ın vitro study

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Field Value
 
Title Prevention of dabigatran ınduced cytotoxicity by N-acetyl cysteine: An ın vitro study
 
Creator Gürpinar, Özer Aylin
Kubat, Emre
 
Subject Antioxidant agent
Apoptosis
Direct thrombin inhibitor
Gastrointestinal upset
 
Description 946-952
Dabigatran (DBG) is an oral direct thrombin inhibitor used for prevention of systemic embolism and venous
thromboembolism. The major side effect of DBG is gastrointestinal upset. In the present study, we have investigated
whether N-acetyl cysteine (NAC) showed a protective effect on dabigatran-induced cytotoxicity in the in vitro setting. The
medium not containing DBG but containing NAC were served to assay the effect of NAC on cell proliferation and
apoptosis. Comparing DAB and all other groups, the cell viability was the lowest in the D group. However, there was no
statistically significant difference between the NAC I and DBG-NAC I group, while the difference was statistically
significant compared to all other groups. The cells in the DBG group showed a degenerative and round-shaped morphology
with nuclear condensation. In other dilutions, the cell morphology was healthy with a fibroblastic morphology. Based on our
study results, NAC at high concentrations exerts cytoprotective effects against DBG, while moderate or low concentrations
have no favorable effect on cell viability of NAC. Although using concomitant NAC at appropriate doses appears to be
effective agent against dabigatran cytotoxicity in the current study, further experimental and clinical studies are needed to
confirm our findings.
 
Date 2023-11-28T06:59:51Z
2023-11-28T06:59:51Z
2023-12
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62964
https://doi.org/10.56042/ijeb.v61i12.2738
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(12) [December 2023]