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Distribution of GABPB1 gene rs7181866 polymorphism in rugby players

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Title Distribution of GABPB1 gene rs7181866 polymorphism in rugby players
 
Creator Yılmaz, Özlem Özge
Polat, Tolga
Eken, Başak Funda
Tuna, Gökhan
Aslan, Beste Tacal
Ulucan, Korkut
 
Subject Athletic performance
Endurance
Nuclear respiration factor
Sport genetics
 
Description 929-932
Nuclear respiration factor 2 is an important respiratory factor for cellular metabolism formed by polypeptides produced
by the GA binding protein transcription factor subunit alpha (GABPA) and GA binding protein transcription factor subunit
beta 1 (GAPPB1) genes. A functional polymorphism on the GABPB1 gene (rs7181866, G/A) alters the cellular respiration
metabolism by affecting the protein dynamics. In this context, here, we examined the distribution of GABPB1 rs718186
polymorphism in professional rugby players to see its relationship with their stamina. Twelve rugby players participated in
the study. Genotyping was performed by Real-Time PCR after DNAs were isolated from blood cells using commercially
available isolation kits. In our cohort, the AA genotype and the A allele were superior to the AG and GG genotypes and the
G allele. There was no statistically significant difference in terms of Genotypes (p=0.9027) and allelic groups (p=0.6948) in
the athlete and control groups. Studies have revealed the relationship between endurance characteristics of athletes and
rs7181866 AA genotype and A allele. These studies will be an important data source for future studies in sports genetics and
GAPPB1 analysis.
 
Date 2023-11-28T07:07:14Z
2023-11-28T07:07:14Z
2023-12
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62967
https://doi.org/10.56042/ijeb.v61i12.4003
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(12) [December 2023]