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Protective effect of Lumbricus rubellus Hoffmeister extract in experimental renal ischemia/reperfusion injury in the nephrectomy rats

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Title Protective effect of Lumbricus rubellus Hoffmeister extract in experimental renal ischemia/reperfusion injury in the nephrectomy rats
 
Creator Öz, Semih
Yıldız, Fatma
Kabay, Şahin
Şentürk, Hakan
Dönmez, Dilek Burukoğlu
Özbayer, Cansu
Üstüner, Mehmet Cengiz
Kaygısız, Bilgin
Çetin, Kısmet Çivi
Özden, Hilmi
 
Subject Antioxidants
Earthworm extract
Kidney
Reactive oxygen species (ROS)
 
Description 911-916
Acute kidney injury (AKI), an immediate loss of renal function, leads to high mortality, and ischemia-reperfusion (I/R)
injury is considered as one of the main causes of AKI. Inflammation and oxidative stress are known to play an important
role in AKI. On the other hand, the earthworm extract, used in traditional medicine, is known to possess various biological
and pharmacological activities viz. antiapoptotic, anticoagulative, fibrinolytic, anti-inflammatory, antioxidative stress,
peripheral nerve regeneration, bone regeneration and wound healing. Hence, in this study, we investigated the protective
effect of the earthworm Lumbricus rubellus Hoffmeister extract (LE) after nephrectomy, against oxidative stress occurring
during renal ischemia/reperfusion (I/R) injury. A total of 10-12 weeks old Sprague Dawley male rats were divided into five
groups (n=8). Group I (control), Group II (I/R), Group III (I/R + 10 mg/kg LE), Group IV (I/R + 20 mg/kg LE) and Group V
(I/R + 40 mg/kg LE). All rats except in Gr. I were applied ischemia for 45 min and reperfusion for 24 h. At the end of the
experiment, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) enzyme activities and
malondialdehyde (MDA) levels were evaluated. In addition, kidney tissues were evaluated histologically. In results, the
MDA and GPx level of the I/R group were found to be significantly higher than the control and LE groups. SOD activity of
the control group did not differ when compared to LE groups and CAT levels were not significantly different between all
groups. In addition, in Gr. III-V we observed nearly normal renal cortex and renal tubules. The present study, thus
demonstrates that the extract of L. rubellus prevents renal I/R injury and induced biochemical and histological changes in
the renal tissues in rats.
 
Date 2023-11-28T07:13:35Z
2023-11-28T07:13:35Z
2023-12
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62969
https://doi.org/10.56042/ijeb.v61i12.1532
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(12) [December 2023]