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Immature mast cells predominate in skin wound repair in senescent mice

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Title Immature mast cells predominate in skin wound repair in senescent mice
 
Creator Macedo, Coelho Monique
Melo, Barreto Rafaela De
De, Resende Juliana Aparecida Pinto
Filipi, Monteiro Juan
De, Castro Rosiane Aparecida
Horta, Pinto Flávia Carmo
Rocha, Carvalho Claudia
Alves, Costa Raquel
 
Subject Aging
Wound healing
 
Description 905-910
Role of mast cells in various phases of skin wound healing is well reported in literature. However, there is much
controversy about the importance of mast cells in skin wound repair. Few studies have demonstrated the presence of mast
cells in skin wound repair in middle-aged and senescent individuals. The mast cells are resident cells in the skin and
participate in the inflammatory process and wound repair response. It is known that there are major changes in the immune
system with aging, including in the skin. In this work, we evaluated the density and maturation of mast cells (mature,
intermediate and immature) at the edges of skin wounds in young, middle-aged and senescent mice by toluidine blue and
alcianine-safranin blue staining. We found that there is a significant decrease in mast cells in senescent mice. There is a
predominance of immature mast cells at all ages 5 days after injury. But the data are intriguing, as in senescent mice there
are fewer mature mast cells. Further studies should be carried out to understand the role of mast cells during aging.
 
Date 2023-11-28T07:15:53Z
2023-11-28T07:15:53Z
2023-12
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62970
https://doi.org/10.56042/ijeb.v61i12.6514
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(12) [December 2023]