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Antidyslipidemic Effect of Naringenin against 5-Fluorouracil Induced Dyslipidemia in Wistar Rats

Indian Agricultural Research Journals

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Title Antidyslipidemic Effect of Naringenin against 5-Fluorouracil Induced Dyslipidemia in Wistar Rats
 
Creator Sravathi Vemula
Jeevanalatha Mylaram
Ravikumar Yadala
Gopalareddy Alla
 
Subject Triglycerides, lipoprotein, erythrocytes, 5-Fluorocytosine
 
Description The present study was conducted in forty adult male rats for 5-Fluorouracil (5-FU) chemotherapeutic drugdyslipidemia toxicity and to evaluate ameliorative effects of Naringenin (NG). The rats were randomly divided into four equal groups:  Group 1 (Normal saline), Group 3 (NG) given orally, Group 2 5-FU (20 mg/kg body weight- five days-intraperitoneally), Group 4 received a combination of 5-FU and ameliorative agent for 28 days. Results showed that 5-FU increased heart weights, altered serum lipid profiles and caused noticeable ventricular hypertrophy. However, Group 4 displayed improved serum lipid levels, reduced heart weights due to mitigative action of ameliorative agent.
 
Publisher Indian Veterinary Association
 
Date 2023-11-09
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://epubs.icar.org.in/index.php/IVJ/article/view/145083
 
Source The Indian Veterinary Journal; Vol. 100 No. 11 (2023); 27-29
0974-9365
0019-6479
 
Language eng
 
Relation https://epubs.icar.org.in/index.php/IVJ/article/view/145083/52940
 
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