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Diagnosis and Management of Canine Hyperadrenocorticism (cHAC)

Indian Agricultural Research Journals

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Title Diagnosis and Management of Canine Hyperadrenocorticism (cHAC)
 
Creator Mohanambal K
Satish Kumar K
Nagaraj P
Lakshman M
Usha Rani M
Ravi Kumar Y
 
Subject alopecia, ketaconazole, mitotane, polyuria
 
Description Canine hyperadrenocorticism (cHAC) in an eleven-year-old male dog was diagnosed through battery tests viz., low-dose dexamethasone suppression test, determination of the urine cortisol to creatinine ratio, and dermato-pathological assessment. Symptoms such as increased thirst, excessive appetite, frequent urination, bilateral hair loss, skin thinning, prominent abdominal blood vessels, and distended abdomen were encountered in the present case. Serum biochemistry analysis revealed high levels of ALP, while dermato-pathological examination revealed abnormalities in the epidermis, sweat gland, sebaceous glands, altered hair follicle morphology.A combined therapy approach was employed, consisting of oral tablets containing ketoconazole (10 mg/kg of body weight) and mitotane. The initial mitotane dose was administered at 50 mg/kg of body weight, followed by a maintenance dose of 25 mg/kg of body weight. Theaffected dogdisplayed significant improvement in two months of therapy.
 
Publisher Indian Veterinary Association
 
Date 2023-12-15
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://epubs.icar.org.in/index.php/IVJ/article/view/146497
 
Source The Indian Veterinary Journal; Vol. 100 No. 12 (2023): December, 2023; 60 - 62
0974-9365
0019-6479
 
Language eng
 
Relation https://epubs.icar.org.in/index.php/IVJ/article/view/146497/53422
 
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